Journal of Pharmaceutical Investigation

The Korean Society of Pharmaceutical Sciences and Technology (한국약제학회)
권호 표지
DOI QR코드

DOI QR Code

Enhanced Dissolution of Coenzyme Q10 using Solid Dispersions Prepared by Low Temperature Melting Method

  • Received : 2010.07.15
  • Accepted : 2010.10.06
  • Published : 2010.10.20
Download PDF
⟨ Previous Next ⟩

Abstract

CoQ with low melting temperature was exploited to improve its solubility by preparing its solid dispersions (SDs) with a meltable polymer, poloxamer 407 (P 407). P407 can be utilized for a relatively simple, quick, inexpensive, reproducible and potentially scalable manner in the low temperature melting method. CoQ 10 solubility and dissolution increased with increasing concentrations of P 407 in SDs. Comparison of the enhanced dissolution of CoQ 10 from different poloxamers suggested that the preparation of CoQ 10 SDs using P 407 as a meltable hydrophilic polymer carrier could be a promising approach to improve its dissolution.

Keywords

References

  1. Chen, Y., Zhang, G.G.Z., Neilly, J., Marsh, K., Mawhinney, D., Sanzgiri, Y.D., 2004. Enhancing the bioavailability of ABT - 963 using solid dispersion containing pluronic F -68, Int. J. Pharm., 286, 69-80. https://doi.org/10.1016/j.ijpharm.2004.08.009
  2. Chopra, R.K., Goldman, R., Sinatra, S.T., Bhagavan, H.N., 1998. Relative bioavailability of coenzyme Q10 formulations in human subjects, Int. J. Vit. Nutr. Res., 68, 109-113.
  3. Chutimaworapan, S., Ritthidej, G.C., Yonemochi, E., Oguchi, T., Yamamoto, K., 2000. Effect of water soluble carriers on dissolution characteristics of nifedipine solid dispersions, Drug Dev. Ind. Pharm., 26, 1141-1150. https://doi.org/10.1081/DDC-100100985
  4. Collett, J.H., Popli, H., 2000. Poloxamers In: A. H. Kibbe, Editor, Handbook of Pharmaceutical Excipients (3rd Edition ed), Pharmaceutical Press, London. pp. 385-388.
  5. Craig, D.Q.M., 2002. The mechanisms of drug release from solid dispersions in water-soluble polymers, Int. J. Pharm., 231, 131-144. https://doi.org/10.1016/S0378-5173(01)00891-2
  6. Craig, D.Q.M., 1990. Polyethylene glycols and drug release, Drug Dev. Ind. Pharm., 16, 2501-2506. https://doi.org/10.3109/03639049009058544
  7. Folkers, K., Wolaniuk, A., Vadhanavikit, S., Sakmato, N., Takemura, K., Baker, L., Richardson, P.C., 1986. Biomedical and clinical research on coenzyme Q10 with emphasis on cardiac patients, In: Folkers, K., Yamamura, Y. (Eds.), Biomedical and Clinical Aspects of Coenzyme Q, Vol.5. Elsevier, Amsterdam, pp. 375-391.
  8. Greenberg, S., Fishman, W.H., 1990. Coenzyme Q10: A new drug for cardiovascular disease, J. Clin. Pharmacol., 30, 590-608.
  9. Hsu, C.H., Cui, Z., Russell, J.M., Michael, J., 2003. Preparation and characterization of novel coenzyme Q10 nanoparticles engineered from microemulsion precursors, AAPS Pharm- SciTech. 4 (3), E32. https://doi.org/10.1208/pt040215
  10. Jones, M.C., Leroux, J.C., 1999. Polymeric micelles- a new generation of colloidal drug carriers, Eur. J. Pharm. Biopharm., 48, 101-111. https://doi.org/10.1016/S0939-6411(99)00039-9
  11. Kabanov, A.V., Batrakova, E.V., Alakhov, V.Y., 2002. Pluronic block copolymers as novel polymer therapeutics for drug and gene delivery, J. Contr. Rel., 82, 189-212. https://doi.org/10.1016/S0168-3659(02)00009-3
  12. Kimura, A., Yamaguchi, H., Watanabe, K., Hayash, I.M., Awazu, S., 1986. Factors influencing the tissue distribution of cownzymq Q10 intravenously administered in an emulsion to rats; emulsifying agents and lipoprotein lipase activity, J. Pharmacol., 38, 659-662. https://doi.org/10.1111/j.2042-7158.1986.tb03105.x
  13. Kishi, H., Kanamori, N., Nishii, S., Hiraoka, E., Okamato, T., Kishi, T., 1984. In: Folkers, K., Yamamura, Y. (Eds.), Biomedical and Clinical Aspects of Coenzyme Q, Elsevier, Amsterdam, pp. 131-142.
  14. Kommurur, T.R., Gurley, B., Khan, M.A., Reddy, I.K., 2001. Selfemulsifying drug delivery systems (SEDDS) of coenzyme Q10: formulation development and bioavailability assessment, Int. J. Pharm., 212, 233-246. https://doi.org/10.1016/S0378-5173(00)00614-1
  15. Lutka, A., Pawlaczyk, J., 1995. Inclusion complexation of coenzyme Q10 with cyclodextrins, Acta Pol. Pharm., 52, 379-386.
  16. Mura, P., Manderioli, A., Bramanti, G., Ceccarelli, L., 1996. Properties of solid dispersions of naproxen in various polyethylene glycols, Drug Dev. Ind. Pharm., 22, 909-916. https://doi.org/10.3109/03639049609065920
  17. Ozawa, Y., Mizushima, Y., Koyama, I., 1986. Intestinal absorption enhancement of coenzyme Q10 with lipid microsphere, Drug Res., 36, 689-690.
  18. Passerini, N., Albertini, B., Perissutti, B., Rodriguez, L., 2006. Evaluation of melt granulation and ultrasonic spray congealing as techniques to enhance the dissolution of praziquantel, Int. J. Pharm., 318, 92-102. https://doi.org/10.1016/j.ijpharm.2006.03.028
  19. Passerini, N., Gonzalez-Rodriguez, M.L., Cavallari, C., Rodriguez, L., Albertini, B., 2002. Preparation and characterisation of ibuprofen- poloxamer 188 granules obtained by melt granulation, Eur. J. Pharm. Sci., 15, 71-78. https://doi.org/10.1016/S0928-0987(01)00210-X
  20. Rouchotas, C., Cassidy, O.E., Rowley, G., 2000. Comparison of surface modification and solid dispersion techniques for drug dissolution, Int. J. Pharm., 195, 1-6. https://doi.org/10.1016/S0378-5173(99)00350-6
  21. Rousseau, G., Varin, F., 1998. Determination of ubiquinone-9 and 10 levels in rat tissues and blood by high-performance liquid chromatography with ultraviolet detection, J. Chromatogr. Sci., 36, 247-52. https://doi.org/10.1093/chromsci/36.5.247
  22. Seo, A., Holm, P., Kristensen, H.G., Schaeer, T., 2003. The preparation of agglomerates containing solid dispersions of diazepam by melt agglomeration in a high shear mixer, Int. J. Pharm., 259, 161-171. https://doi.org/10.1016/S0378-5173(03)00228-X
  23. Serajuddin, A.T.M., 1999. Solid dispersion of poorly water-soluble drugs: early promises, subsequent problems, and recent breakthroughs, J. Pharm. Sci., 88, 1058-1066. https://doi.org/10.1021/js980403l
  24. Shin, S.C., Cho, C.W., 1997. Physicochemical characterizations of piroxicam-poloxamer solid dispersion, Pharm. Dev. Technol., 2, 403-40. https://doi.org/10.3109/10837459709022639
  25. Takada, M., Yuzuriha, T., Katayama, K.,Yamato, C., Koyama, N., 1985. Targeting of Coenzyme Q10 solubilized with soy lecithin to heart of guinea pigs, J. Nutr. Sci. Vitaminol., 31,115- 120. https://doi.org/10.3177/jnsv.31.115
  26. Takeuchi, H., Sasaki, H., Niwa, T., Hino, T., Kawashima, Y., Uesugi, K., Ozawa, H., 1992. Improvement of photostability of ubidecarenone in the formulation of a novel powdered dosage form termed redispersible dry emulsion. Int. J. Pharm., 86, 25-33. https://doi.org/10.1016/0378-5173(92)90027-Y
  27. Vilhelmsen, T., Eliasen, H., Schaeer, T., 2005. Effect of a melt agglomeration process on agglomerates containing solid dispersions, Int. J. Pharm., 303, 132-142. https://doi.org/10.1016/j.ijpharm.2005.07.012
  28. Weis, M., Mortensen, S.A., Rassing, M.R., Moller, S.J., Poulsen, G., Rasmussen, S.N., 1994. Bioavailability of four oral coenzyme Q10 formulations in healthy volunteers, Mol. Aspects Med., 15(suppl): S273-280. https://doi.org/10.1016/0098-2997(94)90038-8
  29. Yu, H., Chun, M.K., Choi, H.K., 2007. Preparation and characterization of piroxicam/poloxamer solid dispersion prepared by melting method and solvent method. J. Kor. Pharm. Sci., 37, 1-5.

Cited by

  1. Development of a Sulglycotide-Loaded Oral Gel with Good Stability and Improved Gastric Ulcer Inhibition vol.73, pp.6, 2012, https://doi.org/10.1002/ddr.21016