생물정신의학 (Korean Journal of Biological Psychiatry)

  • 제17권4호
  • /
  • Pages.177-193
  • /
  • 2010
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  • 1225-8709(pISSN)
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  • 2005-7571(eISSN)
대한생물정신의학회 (The Korean Society of Biological Psychiatry)
권호 표지

외상 후 스트레스 장애의 이해에 있어서 유전학 및 뇌영상 연구의 기여

Contribution of Genetic and Neuroimaging Studies towards a Better Understanding of Post-Traumatic Stress Disorder

  • 김지은 (서울대학교 의과대학 정신과학교실) ;
  • 류인균 (서울대학교 의과대학 정신과학교실) ;
  • 전찬수 (서울대학교 의과대학 정신과학교실) ;
  • 이유상 (용인정신병원)
  • Kim, Ji-Eun E. (Department of Psychiatry, Seoul National University College of Medicine) ;
  • Lyoo, In-Kyoon (Department of Psychiatry, Seoul National University College of Medicine) ;
  • Jun, Chan-Soo (Department of Psychiatry, Seoul National University College of Medicine) ;
  • Lee, Yu-Sang (Yong-In Mental Hospital)
  • 투고 : 2010.09.06
  • 심사 : 2010.10.04
  • 발행 : 2010.11.30
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초록

Significant advances have been made in understanding the biological underpinnings of post-traumatic stress disorder(PTSD), particularly in the field of genetics and neuroimaging. Association studies in candidate genes related with hypothalamic-pituitary-adrenal axis, monoamines including serotonin, dopamine and noradrenaline, and proteins including FK506-binding protein 5 and brain-derived neurotrophic factor have provided important insights with regard to the vulnerability factors in PTSD. Genome-wide association studies and epigenetic studies may provide further information for the role of genes in the pathophysiology of PTSD. Hippocampus, medial prefrontal cortex, anterior cingulated cortex and amygdala have been considered as key structures that underlie PTSD pathophysiology. Future research that combines genetic and neuroimaging information may provide an opportunity for a more comprehensive understanding of PTSD.

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