Journal of Ginseng Research

  • 제34권3호
  • /
  • Pages.155-159
  • /
  • 2010
  • /
  • 1226-8453(pISSN)
  • /
  • 2093-4947(eISSN)
고려인삼학회 (The Korean Society of Ginseng)
권호 표지
DOI QR코드

DOI QR Code

Merit of Ginseng in the Improvement of Insulin Resistance

  • Cheng, Juei-Tang (Department of Medical Research, Chi-Mei Medical Center and Institute of Medical Science, Chang Jung Christian University)
  • 투고 : 2010.07.16
  • 심사 : 2010.08.30
  • 발행 : 2010.09.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

In the present review, the merit of ginseng in the improvement of insulin resistance has been introduced. Using the results in previous studies, we found that ginseng or ginsenoside Rh2 has the ability to reduce glucose-insulin index in rats with insulin resistance. Insulin resistance was induced by feeding of fructose-rich chow in rats. Insulin resistance was characterized by regular methods. Effectiveness of ginseng powder or extract Rh2 was identified in this animal model. Also, the application of ginseng for handling of diabetic disorders in China has been discussed. According to Chinese traditional medicine, ginseng is merit in the treatment of diabetic disorders named as Shiaw-Ker in Chinese. Therefore, it is no doubt that ginseng is helpful in the control of diabetic disorders either prevention or the treatment. Otherwise, the potential effect of ginseng on nervous functions shall be investigated in the future.

키워드

참고문헌

  1. Kruszynska YT, Olefsky JM. Cellular and molecular mechanisms of non-insulin dependent diabetes mellitus. J Investig Med 1996;44:413-428.
  2. Henriksen EJ. Invited review: effects of acute exercise and exercise training on insulin resistance. J Appl Physiol 2002;93:788-796. https://doi.org/10.1152/japplphysiol.01219.2001
  3. Kennedy DO, Scholey AB. Ginseng: potential for the enhancement of cognitive performance and mood. Pharmacol Biochem Behav 2003;75:687-700. https://doi.org/10.1016/S0091-3057(03)00126-6
  4. Block KI, Mead MN. Immune system effects of echinacea, ginseng, and astragalus: a review. Integr Cancer Ther 2003;2:247-267. https://doi.org/10.1177/1534735403256419
  5. Van Kampen J, Robertson H, Hagg T, Drobitch R. Neuroprotective actions of the ginseng extract G115 in two rodent models of Parkinson’s disease. Exp Neurol 2003;184:521-529. https://doi.org/10.1016/j.expneurol.2003.08.002
  6. Kiefer D, Pantuso T. Panax ginseng. Am Fam Physician 2003;68:1539-1542.
  7. Kimura M, Waki I, Tanaka O, Nagai Y, Shibata S. Pharmacological sequential trials for the fractionation of components with hypoglycemic activity in alloxan diabetic mice from ginseng radix. J Pharmacobiodyn 1981;4:402-409. https://doi.org/10.1248/bpb1978.4.402
  8. Kimura M, Suzuki J. The pattern of action of blended Chinese traditional medicines to glucose tolerance curves in genetically diabetic KK-CAy mice. J Pharmacobiodyn 1981;4:907-915. https://doi.org/10.1248/bpb1978.4.907
  9. Yokozawa T, Kobayashi T, Oura H, Kawashima Y. Studies on the mechanism of the hypoglycemic activity of ginsenoside-Rb2 in streptozotocin-diabetic rats. Chem Pharm Bull (Tokyo) 1985;33:869-872. https://doi.org/10.1248/cpb.33.869
  10. Kahn SE. Clinical review 135: the importance of beta-cell failure in the development and progression of type 2 diabetes. J Clin Endocrinol Metab 2001;86:4047-4058. https://doi.org/10.1210/jc.86.9.4047
  11. Kahn CR. Banting Lecture. Insulin action, diabetogenes, and the cause of type II diabetes. Diabetes 1994;43:1066-1084. https://doi.org/10.2337/diab.43.8.1066
  12. Liu TP, Liu IM, Cheng JT. Improvement of insulin resistance by panax ginseng in fructose-rich chow-fed rats. Horm Metab Res 2005;37:146-151. https://doi.org/10.1055/s-2005-861299
  13. Attele AS, Wu JA, Yuan CS. Ginseng pharmacology: multiple constituents and multiple actions. Biochem Pharmacol 1999;58:1685-1693. https://doi.org/10.1016/S0006-2952(99)00212-9
  14. Lee KY, Park JA, Chung E, Lee YH, Kim SI, Lee SK. Ginsenoside-Rh2 blocks the cell cycle of SK-HEP-1 cells at the G1/S boundary by selectively inducing the protein expression of p27kip1. Cancer Lett 1996;110:193-200. https://doi.org/10.1016/S0304-3835(96)04502-8
  15. Park EK, Choo MK, Kim EJ, Han MJ, Kim DH. Antiallergic activity of ginsenoside Rh2. Biol Pharm Bull 2003;26:1581-1584. https://doi.org/10.1248/bpb.26.1581
  16. Lee WK, Kao ST, Liu IM, Cheng JT. Increase of insulin secretion by ginsenoside Rh2 to lower plasma glucose in Wistar rats. Clin Exp Pharmacol Physiol 2006;33:27-32. https://doi.org/10.1111/j.1440-1681.2006.04319.x
  17. Le KA, Tappy L. Metabolic effects of fructose. Curr Opin Clin Nutr Metab Care 2006;9:469-475. https://doi.org/10.1097/01.mco.0000232910.61612.4d
  18. Chang JC, Wu MC, Liu IM, Cheng JT. Increase of insulin sensitivity by stevioside in fructose-rich chow-fed rats. Horm Metab Res 2005;37:610-616. https://doi.org/10.1055/s-2005-870528
  19. Foianini KR, Steen MS, Kinnick TR, Schmit MB, Youngblood EB, Henriksen EJ. Effects of exercise training and ACE inhibition on insulin action in rat skeletal muscle. J Appl Physiol 2000;89:687-694. https://doi.org/10.1152/jappl.2000.89.2.687
  20. Henriksen EJ, Jacob S, Kinnick TR, Teachey MK, Krekler M. Selective angiotensin II receptor receptor antagonism reduces insulin resistance in obese Zucker rats. Hypertension 2001;38:884-890. https://doi.org/10.1161/hy1101.092970
  21. Attele AS, Zhou YP, Xie JT, Wu JA, Zhang L, Dey L, Pugh W, Rue PA, Polonsky KS, Yuan CS. Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component. Diabetes 2002;51:1851-1858. https://doi.org/10.2337/diabetes.51.6.1851
  22. Wang L, Higashiura K, Ura N, Miura T, Shimamoto K. Chinese medicine, Jiang-Tang-Ke-Li, improves insulin resistance by modulating muscle fiber composition and muscle tumor necrosis factor-alpha in fructose-fed rats. Hypertens Res 2003;26:527-532. https://doi.org/10.1291/hypres.26.527
  23. Xie JT, Mehendale SR, Wang A, Han AH, Wu JA, Osinski J, Yuan CS. American ginseng leaf: ginsenoside analysis and hypoglycemic activity. Pharmacol Res 2004;49:113-117. https://doi.org/10.1016/j.phrs.2003.07.015
  24. Cheng JT. Herbs used to treat diabetes mellitus in Chinese traditional medicine. In: Majumdar DK, Govil JN, Singh VK, editors. Recent progress in medicinal plants. Vol. 8, Phytochemistry & pharmacology II. Houston: Sci Tech Publishing, 2003. p.175-184.
  25. Lee WK, Kao ST, Liu IM, Cheng JT. Ginsenoside Rh2 is one of the active principles of Panax ginseng root to improve insulin sensitivity in fructose-rich chow-fed rats. Horm Metab Res 2007;39:347-354. https://doi.org/10.1055/s-2007-976537
  26. Niu CS, Yeh CH, Yeh MF, Cheng JT. Increase of adipogenesis by ginsenoside (Rh2) in 3T3-L1 cell via an activation of glucocorticoid receptor. Horm Metab Res 2009; 41:271-276. https://doi.org/10.1055/s-0028-1103277
  27. Park MY, Lee KS, Sung MK. Effects of dietary mulberry, Korean red ginseng, and banaba on glucose homeostasis in relation to PPAR-alpha, PPAR-gamma, and LPL RNA expressions. Life Sci 2005;77:3344-3354. https://doi.org/10.1016/j.lfs.2005.05.043
  28. Su CF, Chang YY, Pai HH, Liu IM, Lo CY, Cheng JT. Infusion of beta-endorphin improves insulin resistance in fructose-fed rats. Horm Metab Res 2004;36:571-577. https://doi.org/10.1055/s-2004-825763
  29. Lai DM, Tu YK, Liu IM, Chen PF, Cheng JT. Mediation of beta-endorphin by ginsenoside Rh2 to lower plasma glucose in streptozotocin-induced diabetic rats. Planta Med 2006;72:9-13. https://doi.org/10.1055/s-2005-916177
  30. Lee KS, Yu WJ, Wang MJ, Wu HT, Chang CH, Cheng JT. Autonomic regulation of insulin secretion is changed by pentobarbital in mice. Neurosci Lett 2010;479:6-9. https://doi.org/10.1016/j.neulet.2010.05.015
  31. Fisher A, Michaelson DM, Brandeis R, Haring R, Chapman S, Pittel Z. M1 muscarinic agonists as potential disease-modifying agents in Alzheimer’s disease: rationale and perspectives. Ann N Y Acad Sci 2000;920:315-320. https://doi.org/10.1111/j.1749-6632.2000.tb06941.x
  32. Shieh PC, Tsao CW, Li JS, Wu HT, Wen YJ, Kou DH, Cheng JT. Role of pituitary adenylate cyclase-activating polypeptide (PACAP) in the action of ginsenoside Rh2 against beta-amyloid-induced inhibition of rat brain astrocytes. Neurosci Lett 2008;434:1-5. https://doi.org/10.1016/j.neulet.2007.12.032

피인용 문헌

  1. Trends in Ginseng Research in 2010 vol.35, pp.4, 2010, https://doi.org/10.5142/jgr.2011.35.4.389
  2. The Effect of Red Ginseng Extract on Inflammatory Cytokines after Chemotherapy in Children vol.36, pp.4, 2010, https://doi.org/10.5142/jgr.2012.36.4.383
  3. Effects of Natural Bioactive Products on the Growth and Ginsenoside Contents of Panax ginseng Cultured in an Aeroponic System vol.36, pp.4, 2010, https://doi.org/10.5142/jgr.2012.36.4.430
  4. Amelioration of insulin resistance by Rk 1 + Rg 5 complex under endoplasmic reticulum stress conditions vol.6, pp.4, 2010, https://doi.org/10.4103/0974-8490.138257
  5. Antioxidative effects of Korean red ginseng in postmenopausal women: A double-blind randomized controlled trial vol.154, pp.3, 2010, https://doi.org/10.1016/j.jep.2014.04.051