DOI QR코드

DOI QR Code

Java DOM Parsers to Convert KGML into SBML and BioPAX Common Exchange Formats

  • Lee, Kyung-Eun (Department of Computer Science, Ewha Womans University) ;
  • Jang, Myung-Ha (Department of Computer Science, Ewha Womans University) ;
  • Rhie, A-Rang (Department of Computer Science, Ewha Womans University) ;
  • Thong, Chin Ting (Department of Computer Science, Ewha Womans University) ;
  • Yang, San-Duk (Department of Computer Science, Ewha Womans University) ;
  • Park, Hyun-Seok (Department of Computer Science, Ewha Womans University)
  • 심사 : 2010.06.02
  • 발행 : 2010.06.30

초록

Integrating various pathway data collections to create new biological knowledge is a challenge, for which novel computational tools play a key role. For this purpose, we developed the Java-based conversion modules KGML2SBML and KGML2BioPAX to translate KGML (KEGG Markup Language) into a couple of common data exchange formats: SBML (Systems Biology Markup Language) and BioPAX (Biological Pathway Exchange). We hope that our work will be beneficial for other Java developers when they extend their bioinformatics system into SBML- or BioPAX-aware analysis tools. This is part of our ongoing effort to develop an ultimate KEGG-based pathway enrichment analysis system.

키워드

참고문헌

  1. Achard, F., Vaysseix, G., and Barillot, E. (2001). XML, bioinformatics and data integration. Bioinformatics 17, 115-125. https://doi.org/10.1093/bioinformatics/17.2.115
  2. Finney, A., Hucka, M., Bornstein, B.J., Keating, S.M., Shapiro, B.E., Matthews, J., Kovitz, B.L., Schilstra, M.J., Funahashi, A., Doyle, J.C., and Kitano, H. (2006). Software infrastructure for effective communication and reuse of computational models. Systems modeling in cell biology: from concepts to nuts and bolts. MIT Press. pp. 369-378.
  3. Funahashi, A., Jyoraku, A., and Kitano, H. (2004). Converting the KEGG Pathway Database to SBML. 5th Int. Conf. Syst. Biol. (ICSB2004).
  4. Ham, S.I., Song, E.H., Yang, S.D., Thong, C.T., Rhie, A., Galbadrakh, B., Lee, K.E., Park, H.S., and Lee, S.H. (2007). J2.5dPathway: a 2.5D visualization tool to display selected nodes in biological pathways, in parallel planes. Genomics Inform. 7, 171-174.
  5. Hucka, M., Finney, A., Sauro, H.M., Bolouri, H., Doyle, J.C., and Kitano, H. (2003). The systems biology markup language (SBML): a medium for representation and exchange of biochemical network models. Bioinformatics 19, 524-531. https://doi.org/10.1093/bioinformatics/btg015
  6. Jang, M., Whang, J.W., Lewis, E., and Park, H.S. (2010). An interpretation of biological metabolites and their reactions based on relation degree of compound pairs in KEGG XML Files. JSW. 5, 187-194.
  7. Kanehisa, M., and Goto, S. (2000). KEGG: kyoto encyclopedia of genes and genomes. Nucl. Acids Res. 28, 27-30. https://doi.org/10.1093/nar/28.1.27
  8. Moutselos, K., Kanaris, I., Chatziioannou, A., Maglogiannis, I., and Kolisis, F. (2009). KEGG converter: a tool for the in-silico modelling of metabolic networks of the KEGG Pathways database. BMC Bioinformatics 10, 324. https://doi.org/10.1186/1471-2105-10-324
  9. Stromback, L., and Lambrix, P. (2005). Representations of molecular pathways: an evaluation of SBML, PSI MI and BioPAX. Bioinformatics 21, 4401-4407. https://doi.org/10.1093/bioinformatics/bti718