Genomics & Informatics

  • 제8권2호
  • /
  • Pages.90-93
  • /
  • 2010
  • /
  • 1598-866X(pISSN)
  • /
  • 2234-0742(eISSN)
한국유전체학회 (Korea Genome Organization)
권호 표지
DOI QR코드

DOI QR Code

AKAPDB: A-Kinase Anchoring Proteins Database

  • Kim, In-Sil (Neurovascular Coordination Research Center, College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University) ;
  • Lim, Kyung-Joon (Neurovascular Coordination Research Center, College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University) ;
  • Han, Bok-Ghee (Center for Genome Science, National Institute of Health, Korea Center for Disease Control and Prevention) ;
  • Chung, Myung-Guen (Center for Genome Science, National Institute of Health, Korea Center for Disease Control and Prevention) ;
  • Kim, Kyu-Won (Neurovascular Coordination Research Center, College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University)
  • 심사 : 2010.05.22
  • 발행 : 2010.06.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

A-kinase-anchoring proteins (AKAPs) are scaffold proteins which compartmentalize protein kinase A (PKA, cAMP-dependent protein kinase) and other enzymes to specific subcellular sites. The spatiotemporal control of these enzymes by AKAPs is important for cellular function like cell growth and development etc. Hence, it is important to understand the basic function of AKAPs and their functional domains. However, diverse names, function, cellular localizations and many members of AKAPs increase difficulties when researchers search appropriate AKAPs for their experimental purpose. Nevertheless, there was no previous AKAPs-related database regardless of their important cellular functions and difficulty of finding appropriate AKAPs. So, we developed AKAPs database (AKAPDB), which contains their sequence information, functions and other information derived from prediction programs and other databases. Therefore, we propose that AKAPDB can be an important tool to researchers in the related fields. AKAPDB is available via the internet at http://plaza3.snu.ac.kr/akapdb/.

키워드

참고문헌

  1. Bishop, M.J. (1999). Genetics Databases. London: Academic Press, A Harcourt Science and Technology Company.
  2. Colledge, M., and Scott, J.D. (1999). AKAPs: from structure to function. Trends Cell Biol . 9, 216-221. https://doi.org/10.1016/S0962-8924(99)01558-5
  3. Fink, J.L., Aturaliya, R.N., Davis, M.J., Zhang, F., Hanson, K., Teasdale, M.S., Kai, C., Kawai, J., Carninci, P., Hayashizaki, Y., and Teasdale, R.D. (2006). LOCATE: a mouse protein subcellular localization database. Nucl. Acids Res . 34, D213-D217. https://doi.org/10.1093/nar/gkj069
  4. Francis, S.H., and Corbin, J.D. (1994). Structure and function of cyclic nucleotide-dependent protein kinases. Annu. Rev. Physiol. 56, 237-272. https://doi.org/10.1146/annurev.ph.56.030194.001321
  5. Letunic, I., Doerks, T., and Bork, P. (2008). SMART 6: recent updates and new developments. Nucl. Acids Res . 37, D229-D232.
  6. McConnachie, G., Langeberg, L.K., and Scott, J.D. (2006). AKAP signaling complexes: getting to the heart of the matter. Trends Mol. Med . 12, 317-323. https://doi.org/10.1016/j.molmed.2006.05.008
  7. Michel, J.J.C., and Scott, J.D. (2002). AKAP mediated signal transduction. Annu. Rev. Pharmacol. Toxicol . 42, 235-257. https://doi.org/10.1146/annurev.pharmtox.42.083101.135801
  8. Nasevicius, A., and Ekker, S.C. (2000). Effective targeted gene 'knockdown' in zebrafish. Nat. Genet. 26, 216-220. https://doi.org/10.1038/79951
  9. Pierleoni, A., Martelli, P.L., Fariselli, P., and Casadio, R. (2007). eSLDB: eukaryotic subcellular localization database. Nucl. Acids Res . 35, D208-D212. https://doi.org/10.1093/nar/gkl775
  10. Rubin, C.S. (1994). A kinase anchor proteins and the intracellular targeting of signals carried by cyclic AMP. Biochim. Biophys. Acta . 1224, 467-479.
  11. Scott, J.D. (1991). Cyclic nucleotide-dependent protein kinases. Pharmac. Ther . 50, 123-145. https://doi.org/10.1016/0163-7258(91)90075-W
  12. Scott, J.D., and Pawson, T. (2000). Cell communication: the inside story. Sci. Am. 282, 72-79.
  13. Wheeler, D.L., Barrett, T., Benson, D.A., Bryant, S.H., Canese, K., Chetvernin, V., Church, DM., DiCuccio, M., Edgar, R., Federhen, S., Geer, L.Y., Kapustin, Y., Khovayko, O., Landsman, D., Lipman, D.J., Madden, T.T., Maglott, D.R., Ostell, J., Miller, V., Pruitt, K.D., Schuler, G.D., Sequeira, E., Sherry, S.T., Sirotkin, K., Souvorov, A., Starchenko, G., Tatusov, R.L., Tatusova, T.A., Wagner, L., and Yaschenko, Y. (2006). Database resources of the National Center for Biotechnology Information. Nucl. Acids Res . 34, D173-D180. https://doi.org/10.1093/nar/gkj158
  14. Wheeler, D.L., Church, D.M., Federhen, S., Lash, A.E., Madden, T.L., Pontius, J.U., Schuler, G.D., Schriml, L. M., Sequeira, E., Tatusova, T.A., and Wagner, L. (2003). Database resources of the National Center for Biotechnology. Nucl. Acids Res . 31, 28-33. https://doi.org/10.1093/nar/gkg033
  15. Wong, W., and Scott, J.D. (2004). AKAP signalling complexes: focal points in space and time. Nat. Rev. Mol. Cell Bio. 5, 959-970. https://doi.org/10.1038/nrm1527
  16. Xue, Y., and Ren, J. (2009). GPS Manual. Group-based Prediction System, Version 2.1.1. 1-24.
  17. Xue, Y., Ren, J., Gao, X., Jin, C., Wen, L., and Yao, X. (2008). GPS 2.0: Prediction of Kinase-Specific Phosphorylation Sites in Hierarchy. Mol. Cell Proteomics 7, 1598-1608. https://doi.org/10.1074/mcp.M700574-MCP200