References
- Arking, D.E., Cutler, D.J., Brune, C.W., Teslovich, T.M., West, K., Ikeda, M., Rea, A., Guy, M., Lin, S., Cook, E.H., and Chakravarti, A. (2008). A common genetic variant in the neurexin superfamily member CNTNAP2 increases familial risk of autism. Am. J. Hum. Genet. 82, 160-164. https://doi.org/10.1016/j.ajhg.2007.09.015
- Bailey, A., Le Couteur, A., Gottesman, I., Bolton, P., Simonoff, E., Yuzda, E., and Rutter, M. (1995). Autism as a strongly genetic disorder: evidence from a British twin study. Psychol. Med. 25, 63-77. https://doi.org/10.1017/S0033291700028099
- Boulanger, L.M., Huh, G.S., and Shatz, C.J. (2001). Neuronal plasticity and cellular immunity: shared molecular mechanisms. Curr. Opin. Neurobiol. 11, 568-578. https://doi.org/10.1016/S0959-4388(00)00251-8
- Christian, S.L., Brune, C.W., Sudi, J., Kumar, R.A., Liu, S., Karamohamed, S., Badner, J.A., Matsui, S., Conroy, J., McQuaid, D., Gergel, J., Hatchwellm, E., Gilliam, T.C., Gershon, E.S., Nowak, N.J., Dobyns, W.B., and Cook, E.H. Jr. (2008). Novel submicroscopic chromosomal abnormalities detected in autism spectrum disorder. Biol. Psychiatry 63, 1111-1117. https://doi.org/10.1016/j.biopsych.2008.01.009
- Cohly, H.H., and Panja, A. (2005). Immunological findings in autism. Int. Rev. Neurobiol. 71, 317-341. https://doi.org/10.1016/S0074-7742(05)71013-8
- Cook, E.H. Jr., and Scherer, S.W. (2008). Copy-number variations associated with neuropsychiatric conditions. Nature 455, 919-923. https://doi.org/10.1038/nature07458
- Currier, J.R., Deulofeut, H., Barron, K.S., Kehn, P.J., and Robinson, M.A. (1996). Mitogens, superantigens, and nominal antigens elicit distinctive patterns of TCRB CDR3 diversity. Hum. Immunol. 48, 39-51. https://doi.org/10.1016/0198-8859(96)00076-6
- Dauwerse, J.G., Ruivenkamp, C.A., Hansson, K., Marijnissen, G.M., Peters, D.J., Breuning, M.H., and Hilhorst- Hofstee, Y. (2010). A complex chromosome 7q rearrangement identified in a patient with mental retardation, anxiety disorder, and autistic features. Am. J. Med. Genet. A 152A, 427-433. https://doi.org/10.1002/ajmg.a.33203
- Denney, D.R., Frei, B.W., and Gaffney, G.R. (1996). Lymphocyte subsets and interleukin-2 receptors in autistic children. J. Autism. Dev. Disord. 26, 87-97. https://doi.org/10.1007/BF02276236
- Folstein, S.E., and Rosen-Sheidley, B. (2001). Genetics of autism: complex aetiology for a heterogeneous disorder. Nat. Rev. Genet. 2, 943-955. https://doi.org/10.1038/35103559
- Freeman, J.L., Perry, G.H., Feuk, L., Redon, R., McCarroll, S.A., Altshuler, D.M., Aburatani, H., Jones, K.W., Tyler-Smith, C., Hurles, M.E., Carter, N.P., Scherer, S.W., and Lee, C. (2006). Copy number variation: new insights in genome diversity. Genome Res. 16, 949-961. https://doi.org/10.1101/gr.3677206
- Gu, W., and Lupski, J.R. (2008). CNV and nervous system diseases--what's new? Cytogenet. Genome Res. 123, 54-64. https://doi.org/10.1159/000184692
- Gupta, S. (2000). Immunological treatments for autism. J. Autism Dev. Disord. 30, 475-479. https://doi.org/10.1023/A:1005568027292
- Klauck, S.M. (2006). Genetics of autism spectrum disorder. Eur. J. Hum. Genet. 14, 714-720. https://doi.org/10.1038/sj.ejhg.5201610
- Marshall, C.R., Noor, A., Vincent, J.B., Lionel, A.C., Feuk, L., Skaug, J., Shago, M., Moessner, R., Pinto, D., Ren, Y., Thiruvahindrapduram, B., Fiebig, A., Schreiber, S., Friedman, J., Ketelaars, C.E., Vos, Y.J., Ficicioglu, C., Kirkpatrick, S., Nicolson, R., Sloman, L., Summers, A., Gibbons, C.A., Teebi, A., Chitayat, D., Weksberg, R., Thompson, A., Vardy, C., Crosbie, V., Luscombe, S., Baatjes, R., Zwaigenbaum, L., Roberts, W., Fernandez, B., Szatmari, P., and Scherer, S.W. (2008). Structural variation of chromosomes in autism spectrum disorder. Am. J. Hum. Genet. 82, 477-488. https://doi.org/10.1016/j.ajhg.2007.12.009
- McCauley, J.L., Li, C., Jiang, L., Olson, L.M., Crockett, G., Gainer, K., Folstein, S.E., Haines, J.L., and Sutcliffe, J.S. (2005). Genome-wide and Ordered-Subset linkage analyses provide support for autism loci on 17q and 19p with evidence of phenotypic and interlocus genetic correlates. BMC Med. Genet. 6, 1.
- Merikangas, A.K., Corvin, A.P., and Gallagher, L. (2009). Copy-number variants in neurodevelopmental disorders: promises and challenges. Trends Genet. 25, 536-544. https://doi.org/10.1016/j.tig.2009.10.006
- Redon, R., Ishikawa, S., Fitch, K.R., Feuk, L., Perry, G.H., Andrews, T.D., Fiegler, H., Shapero, M.H., Carson, A.R., Chen, W., Cho, E.K., Dallaire, S., Freeman, J.L., Gonzalez, J.R., Gratacos, M., Huang, J., Kalaitzopoulos, D., Komura, D., MacDonald, J.R., Marshall, C.R., Mei, R., Montgomery, L., Nishimura, K., Okamura, K., Shen, F., Somerville, M.J., Tchinda, J., Valsesia, A., Woodwark, C., Yang, F., Zhang, J., Zerjal, T., Zhang, J., Armengol, L., Conrad, D.F., Estivill, X., Tyler-Smith, C., Carter, N.P., Aburatani, H., Lee, C., Jones, K.W., Scherer S,W., and Hurles, M.E. (2006). Global variation in copy number in the human genome. Nature 444, 444-454. https://doi.org/10.1038/nature05329
- Risch, N., Spiker, D., Lotspeich, L., Nouri, N., Hinds, D., Hallmayer, J., Kalaydjieva, L., McCague, P., Dimiceli, S., Pitts, T., Nguyen, L., Yang, J., Harper, C., Thorpe, D., Vermeer. S., Young, H., Hebert. J., Lin, A., Ferguson, J., Chiotti, C., Wiese-Slater, S., Rogers,T., Salmon, B., Nicholas, P., Petersen, P.B., Pingree, C., McMahon, W., Wong, D.L., Cavalli-Sforza, L.L., Kraemer, H.C., and Myers, R.M. (1999). A genomic screen of autism: evidence for a multilocus etiology. Am. J. Hum. Genet. 65, 493-507. https://doi.org/10.1086/302497
- Rutter, M. (2005). Autism research: lessons from the past and prospects for the future. J. Autism Dev. Disord. 35, 241-257. https://doi.org/10.1007/s10803-004-2003-9
- Santangelo, S.L., and Tsatsanis, K. (2005). What is known about autism: genes, brain, and behavior. Am. J. Pharmacogenomics 5, 71-92.
- Schanen, N.C. (2006). Epigenetics of autism spectrum disorders. Hum. Mol. Genet. 15, 138-150. https://doi.org/10.1093/hmg/ddl213
- Sweeten, T.L., Bowyer, S.L., Posey, D.J., Halberstadt, G.M., and McDougle, C.J. (2003). Increased prevalence of familial autoimmunity in probands with pervasive developmental disorders. Pediatrics 112, 420. https://doi.org/10.1542/peds.112.5.e420
- Syken, J., and Shatz, C.J. (2003). Expression of T cell receptor beta locus in central nervous system neurons. Proc. Natl. Acad. Sci. 100, 13048-13053. https://doi.org/10.1073/pnas.1735415100
- Van Gent, T., Heijnen, C.J., and Treffers, P.D. (1997). Autism and the immune system. J. Child. Psychol. Psychiatry 38, 337-349. https://doi.org/10.1111/j.1469-7610.1997.tb01518.x
- Vargas, D.L., Nascimbene, C., Krishnan, C., Zimmerman, A.W., and Pardo, C.A. (2005). Neuroglial activation and neuroinflammation in the brain of patients with autism. Ann. Neurol. 57, 67-81. https://doi.org/10.1002/ana.20315
- Vorstman, J.A., Staal, W.G., van Daalen, E., van Engeland, H., Hochstenbach, P.F., and Franke, L. (2006). Identification of novel autism candidate regions through analysis of reported cytogenetic abnormalities associated with autism. Mol. Psychiatry 11, 18-28. https://doi.org/10.1038/sj.mp.4001757
- Yim, S.H., Kim, T.M., Hu, H.J., Kim, J.H., Kim, B.J., Lee, J.Y., Han, B.G., Shin, S.H., Jung, S.H., and Chung, Y.J. (2010). Copy number variations in East-Asian population and their evolutionary and functional implications. Hum. Mol. Genet. 19, 1001-1008. https://doi.org/10.1093/hmg/ddp564
- Zhao, T.M., Whitaker, S.E., and Robinson, M.A. (1994). A genetically determined insertion/deletion related polymorphism in human T cell receptor beta chain (TCRB) includes functional variable gene segments. J. Exp. Med. 180, 1405-1414. https://doi.org/10.1084/jem.180.4.1405