한국임상수의학회지 (Journal of Veterinary Clinics)

  • 제27권3호
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  • Pages.257-261
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  • 2010
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  • 1598-298X(pISSN)
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  • 2384-0749(eISSN)
한국임상수의학회 (The Korean Society of Veterinary Clinics)
권호 표지

흰쥐 급성 대사성 알칼리증과 호흡성 알칼리증 모델에서 혈액 전해질 및 대사산물

Blood Electrolytes and Metabolites in Rat Model of Acute Metabolic and Respiratory Alkalosis

  • 김상진 (전북대학교 수의과대학) ;
  • 이문영 (전북대학교 수의과대학) ;
  • 김진상 (전북대학교 인수공통전염병연구소) ;
  • 강형섭 (전북대학교 인수공통전염병연구소)
  • Kim, Shang-Jin (College of Veterinary Medicine, Chonbuk National University) ;
  • Lee, Mun-Young (College of Veterinary Medicine, Chonbuk National University) ;
  • Kim, Jin-Shang (Korean Zoonoses Research Institute, Chonbuk National University) ;
  • Kang, Hyung-Sub (Korean Zoonoses Research Institute, Chonbuk National University)
  • 심사 : 2010.06.15
  • 발행 : 2010.06.30
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초록

산염기 불균형과 수반되는 치료과정에서 혈액 이온들은 변동되어 질 수 있다. 생리적 그리고 생물학적 활성을 가진 순환 이온화 $Mg^{2+}$ 측정이 수의 임상분야에도 적용되고 있다. 실험동물모델에서 급성 대사성 알칼리증 및 호흡성 알칼리증에 수반하는 혈액 이온화 $Mg^{2+}$ 변동을 관찰하였다. 대사성 알칼리증은 $NaHCO_3$ 정맥투여로 그리고 호흡성 알칼리증은 과호흡에 의해 유도하였다. 혈액 이온화 $Mg^{2+}$은 $NaHCO_3$에 의해 유도된 대사성 알칼리증에서는 가역적인 감소를 보인 반면, 과호흡에 의해 유도된 호흡성 알칼리증에서는 비가역적인 증가를 보였다. 따라서 산염기 불균형 치료에 있어 혈액 이온화 $Mg^{2+}$의 잠재적 변동 가능성을 고려하여야 한다고 판단된다.

The development of blood ionic changes could be precipitated in acid-base disorder and subsequent treatment. As technology for detecting circulating ionized $Mg^{2+}$ (the most interesting form with respect to physiological and biological properties) is now available in veterinary clinical medicine. This present study investigated the changes of whole blood ionized $Mg^{2+}$ correlated with acute metabolic and respiratory alkalosis in rodent model. Metabolic alkalosis was induced by intravenous infusion with $NaHCO_3$ and mechanical hyperventilation was applied for respiratory alkalosis. We founded that the blood ionized $Mg^{2+}$ could be reversibly decreased by the $NaHCO_3$-induced acute metabolic alkalosis but irreversibly increased by the mechanical hyperventilation-induced respiratory acidosis and respiratory acidosis. We suggested that the potential change in blood suggested that the potential change in blood ionized $Mg^{2+}$ should be counted in treatment of acid-base disorders.

키워드

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