Natural Product Sciences

  • 제16권3호
  • /
  • Pages.148-152
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  • 2010
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  • 1226-3907(pISSN)
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  • 2288-9027(eISSN)
한국생약학회 (The Korean Society of Pharmacognosy)
권호 표지

Microbial Metabolism of Yangonin, a Styryl Lactone from Piper methysticum (Kava)

  • Kim, Ji-Hye (Marine Natural Products Chemistry Laboratory, Korea Ocean Research & Development Institute) ;
  • Kim, Hyun-Jung (Medical Research Center for Gene Regulation and the Brain Korea 21 Project, Chonnam National University Medical School) ;
  • Lee, Ik-Soo (College of Pharmacy and Research Institute of Drug Development, Chonnam National University)
  • 투고 : 2010.08.26
  • 심사 : 2010.09.08
  • 발행 : 2010.09.30
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초록

Microbial metabolism studies of yangonin (1), a major styryl lactone from Piper methysticum, have resulted in the production of three hydroxylated metabolites (2-4). The chemical structures of these compounds were elucidated to be 4-methoxy-6-(12-hydroxystyryl)-2-pyrone (2),4-methoxy-6-(11,12-dihydroxystyryl)-2-pyrone (3),and 4,12-dimethoxy-6-(7,8-dihydroxy-7,8-dihydrostyryl)-2-pyrone (4) on the basis of the chemical and spectroscopic analyses. The compounds 3 and 4 are reported herein as microbial metabolites of yangonin for the first time.

키워드

참고문헌

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