Journal of Plant Biotechnology

The Korean Society of Plant Biotechnology (한국식물생명공학회)
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Plant-based production of therapeutic antibodies

식물기반 치료용 항체생산

  • Kim, Young-Kwan (Department of Biological Science, College of Natural ciences, Wonkwang University) ;
  • So, Yang-Kang (Department of Biological Science, College of Natural ciences, Wonkwang University) ;
  • Park, Da-Young (Department of Biological Science, College of Natural ciences, Wonkwang University) ;
  • Kim, Hyun-Soon (Plant systems engineering research center, Korea Research Institute of Bioscience and Biotechnology) ;
  • Jeon, Jae-Heung (Plant systems engineering research center, Korea Research Institute of Bioscience and Biotechnology) ;
  • Choo, Young-Kug (Department of Biological Science, College of Natural ciences, Wonkwang University) ;
  • Ko, Ki-Sung (Department of Biological Science, College of Natural ciences, Wonkwang University)
  • 김영관 (원광대학교 생명과학부) ;
  • 소양강 (원광대학교 생명과학부) ;
  • 박다영 (원광대학교 생명과학부) ;
  • 김현순 (한국생명공학연구원 식물시스템공학연구센터) ;
  • 전재흥 (한국생명공학연구원 식물시스템공학연구센터) ;
  • 추영국 (원광대학교 생명과학부) ;
  • 고기성 (원광대학교 생명과학부)
  • Received : 2010.08.04
  • Accepted : 2010.08.18
  • Published : 2010.09.30
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Abstract

Antibodies are powerful and versatile tools to play a critical role in the diagnosis and treatment of many diseases. Their application has been enhanced significantly with the advanced recombinant DNA and heterologonous expression technologies, allowing to produce immunotherapeutic proteins with improved biofunctional properties. However, with currently available technologies, mammalian cell-based therapeutic antibody production, as an alternative for production in humans and animals, is often not plentiful for passive immunotherapeutics in treatment of many diseases. Recently, plant expression systems for therapeutic antibodies have become well-established. Thus, plants have been considered to provide an attractive alternative production system for therapeutic antibodies, as plants have several advantages such as the lack of human pathogens, and low cost of upstream production and flexible scale-up of highly valuable recombinant glycoproteins. Recent advances in modification of posttranslational processing for human-like glycosylation in transgenic plants will make it possible that plant can become a suitable protein expression system over the animal cellbased current production system. This review will discuss recent advances in plant expression technology and issues for their application to therapeutic antibody production.

Keywords

References

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