YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
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Synthesis of 7-Aryloxy-chroman-2-carboxamides and their Evaluation of NF-${\kappa}B$ Inhibitory Activities

7-아릴옥시-크로만-2-카복사마이드 유도체들의 합성 및 NF-${\kappa}B$ 저해활성

  • Received : 2010.06.02
  • Accepted : 2010.06.06
  • Published : 2010.06.30
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Abstract

Nuclear factor-${\kappa}B$ (NF-${\kappa}B$) plays critical roles in physiological and pathological processes such as immune function, cellular growth, homeostasis, apoptosis, and inflammation. As part of our ongoing efforts to develop novel NF-${\kappa}B$ inhibitory agents, we reported that KL-1156 (6-hydroxy-7-methoxychroman-2-carboxylic acid phenylamide) exhibited potent inhibitory activity of NF-${\kappa}B$. For further structure-activity relationship, a series of 7-aryloxy-chroman-2-carboxylamide derivatives were synthesized to explore their inhibitory activities of NF-${\kappa}B$.

Keywords

References

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