Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Cytoprotective and Anti-inflammatory Effects of Nardostachys jatamansi Water Extract Via Expression of HO-1

감송향물추출물의 HO-1 발현 촉진을 통한 세포보호 작용 및 항염작용

  • Park, Chul (Department of Physiology, School of Oriental Medicine & Research Center of Traditional Korean Medicine, Wonkwang University) ;
  • Zheng, Min (Department of Medical Science, College of Medicine University of Ulsan) ;
  • Seo, Eun-A (Department of Food and Nutrition, College of Human Environmental Science, Wonkwang University) ;
  • Kwon, Kang-Beom (Department of Physiology, School of Oriental Medicine & Research Center of Traditional Korean Medicine, Wonkwang University) ;
  • Ryu, Do-Gon (Department of Physiology, School of Oriental Medicine & Research Center of Traditional Korean Medicine, Wonkwang University)
  • 박철 (원광대학교 한의과대학 생리학교실 & 한국전통의학연구소) ;
  • 정민 (울산대학교 의과대학 의과학과) ;
  • 서은아 (원광대학교 생활과학대학 식품영양학과) ;
  • 권강범 (원광대학교 한의과대학 생리학교실 & 한국전통의학연구소) ;
  • 유도곤 (원광대학교 한의과대학 생리학교실 & 한국전통의학연구소)
  • Received : 2010.07.09
  • Accepted : 2010.08.14
  • Published : 2010.08.25
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Abstract

Nardostachys jatamansi water extract (NJ) has long been used for the treatment of inflammation-and immune-mediated disorders in the oriental countries. However, its site of action and pharmacological mechanism are not fully investigated. In this study, the authors tried to explore the cytoprotective and anti-inflammatory actions of NJ. First of all, NJ has no harmful effects on viability of neuronal cell line HT22 cells in the dose range of 300 mg/ml. On the contrary, it shows cytoprotective effects on the cells treated with reactive oxygen species H2O2. Probably the cytoprotective effects of NJ might be caused by its ability to induce well known cytoprotective gene hem oxygenase-1 (HO-1). Furthermore, NJ shows inhibitory effects on the expression of inducible nitric oxide synthase (iNOS) and NO production which are known to destroy the integrity of both cells and tissues. It also inhibits potent proinflammatory cytokine tumor necrosis factor-alpha (TNF-a) production. The blocking effects of NJ on cytopathic and proinflammatory actions of LPS might be caused by the induction of cytoprotective and anti-inflammatory genes HO-1 in macrophages cell line RAW 264.7 cells. The results in this study suggest NJ could be used for the amelioration of inflammation which is underlying mechanism responsible for most chronic diseases.

Keywords

References

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