대한의용생체공학회:의공학회지 (Journal of Biomedical Engineering Research)

  • 제31권2호
  • /
  • Pages.99-105
  • /
  • 2010
  • /
  • 1229-0807(pISSN)
  • /
  • 2288-9396(eISSN)
대한의용생체공학회 (The Korean Society of Medical and Biological Engineering)
권호 표지
DOI QR코드

DOI QR Code

미세튜브 내부를 흐르는 혈액유동의 유변학적 특성에 대한 in-vitro 연구

In-vitro Study on Hemorheological Behaviors of Blood Flow Through a Micro Tube

  • 강명진 (기술보증기금, 부산기술평가센터) ;
  • 지호성 (부산대학교 기계공학부)
  • 투고 : 2009.09.21
  • 심사 : 2010.03.08
  • 발행 : 2010.04.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

In order to obtain velocity profile of blood flow with high spatial resolution, a micro PIV technique consisted of a fluorescent microscope, double-pulsed YAG laser, cooled CCD camera was applied to in-vitro blood flow experiment through a micro round tube of a diameter $100{\mu}m$. Velocity distributions of blood flow for rabbit were obtained. The viscosity profiles for shear rate were found at flowing condition. To provide hemorheological characteristics of blood flow, the viscosities for shear rate were evaluated. The viscosity of blood also steeply increase by decreasing shear rate resulting in Non-Newtonian flow, especially in low shear rate region caused by RBC rheological properties. The results show typical characteristics of Non-Newtonian characteristics from the results of velocity profile and viscosity for blood flow. From the inflection points, cell free layer and two-phase flow consisted with plasma and suspensions including RBCs can be separated.

키워드

참고문헌

  1. C. Pickart, J. M. Piau, and H. Galliard, "Human blood shear yield stress and its hematocrit dependence," Journal of Rheology, Vol. 42, pp. 1-12, 1998. https://doi.org/10.1122/1.550883
  2. U. Windberger, A. Bartholovitsch, R. Plasenzotti, K. J. Korak, and G. Heinze, "Whole blood viscosity, plasma viscosity and erythrocyte aggregation in nine mammalian species: reference values and comparison data," Experimental Physiology, Vol. 88, pp. 431-440, 2003. https://doi.org/10.1113/eph8802496
  3. H. L. Goldsmith, "The microrheology of human blood," Microvascular Research, 31, pp. 121-142, 1986. https://doi.org/10.1016/0026-2862(86)90029-4
  4. J. J. Bishop, P. R. Nance, A.S. Popel, M. Intaglietta, and P. C. Johnson, "Effect of erythrocyte aggregation on velocity profiles in venules," American Journal of Physiology-Heart Circulation Physiology, Vol.280, pp. 222-236, 2001.
  5. O. K, Baskurt, and J, H. Meilselm, "Blood Rheology and Hemodynamics," Seminars in Thrombosis and Hemostatisis, Vol. 29, pp. 435-450, 2003. https://doi.org/10.1055/s-2003-44551
  6. P. F. Davis, "Hemodynamic shear stress and the endothelium in cardiovascular pathophysiology," Nature Clinical Practice Cardiovascular Medicine, Vol. 16, pp. 16-26, 2009.
  7. Y. Sugii, S. Nishio, and K. Okamoto, "In vivo PIV measurement of red blood cell velocity field in microvessels considering mesentery motion," Physiological Measurement, Vol. 23, pp. 403-416, 2002. https://doi.org/10.1088/0967-3334/23/2/315
  8. S, S. Shevkoplyas, S. C. Gifford，T. Yoshida, and M. W. Bitensky, "Prototype of an in vitro model of microcirculation," Microvascular Research, Vol.65, pp. 132-136, 2003. https://doi.org/10.1016/S0026-2862(02)00034-1
  9. C.D. Meinhart, S.T. Wereley, and M.H.B. Gray, "Volume illumination for two-dimensional particle image velocimety," Measurement Science and Technology, Vol 11, pp. 809-814, 2000. https://doi.org/10.1088/0957-0233/11/6/326