Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
권호 표지

Hepatocellular Carcinoma in a Cocker Spaniel Dog with Hypoglycemia

저혈당증을 동반한 코커스파니엘견에서의 간선암종 증례

  • Kang, Min-Hee (BK21 Basic & Diagnostic Veterinary Specialist Program for Animal Deseases and Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University) ;
  • Yoo, Jong-Hyun (BK21 Basic & Diagnostic Veterinary Specialist Program for Animal Deseases and Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University) ;
  • Park, Hee-Myung (BK21 Basic & Diagnostic Veterinary Specialist Program for Animal Deseases and Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University)
  • 강민희 (건국대학교 수의과대학 내과학교실) ;
  • 유종현 (건국대학교 수의과대학 내과학교실) ;
  • 박희명 (건국대학교 수의과대학 내과학교실)
  • Accepted : 2009.04.14
  • Published : 2010.04.30
Download PDF
⟨ Previous Next ⟩

Abstract

A 5-year-old male Cocker spaniel was presented with an abrupt seizure episode. The dog was moderately dehydrated, hypersalivation and loss of consciousness at the presentation. Tentative diagnosis was made through history taking, clinical signs, physical examination, neurologic examination, basic laboratory examinations, radiological examination and cytologic examination. In addition, serum alpha-fetoprotein (AFP) value was measured to diagnose in this case. The serum AFP concentration was marked elevated (1513.5 ng/ml). The patient was suspected as HCC and medical therapy was initiated to control hypoglycemic-associated seizure. However, the dog was euthanized because of the owner's request. It was diagnosed as hepatocellular carcinoma (HCC) based on the histopathologic examination. This case indicates that AFP measurement might be valuable to diagnose HCC in dogs.

5년령의 수컷 코커스파니엘견이 갑작스런 발작증상으로 내원하였다. 내원당시 중등도의 탈수, 과다유연이 관찰되었고, 의식이 소실된 상태였다. 신체검사상 상복부에서 복강내 종괴가 촉진되었고, 실험실 검사에서 저혈당증과 간효소 수치의 상승이 관찰되었다. 진단으로는 병력, 임상증상, 신체검사, 신경검사, 기본적 실험실 검사와 방사선 검사 및 세포검사가 이용되었다. 특히 원발성 간 선암종이 의심되어 혈청 중 alpha-fetoprotein (AFP)을 측정하였다. 혈청 중 AFP 수치는 특이적으로 정상견에 비해 매우 높은 수준이었다(1513.5 ng/ml). 이 환축은 원발성 간 선암종이 의심이 되었으며 이로 인한 저혈당으로 발작증상을 관리하기 위해 포도당투여를 포함한 약물치료가 시작되었다. 하지만, 보호자의 요청에 의해 안락사가 실시되었고 부검 후 조직 검사를 통하여 원발성 간 선암종으로 확진되었다. 결론적으로 본증례의 경우 개에서 원발성 간암의 진단에 혈청 중 AFP 측정이 진단에 유용할 수 있음을 보여주는 증례다.

Keywords

References

  1. Abelev GI. Production of embryonal serum a-globulin by hepatomas: review of experimental and clinical data. Cancer Res 1986; 28: 1344-1350.
  2. Ablelev GI, Eraiser TL. Cellular aspects of alpha-fetoprotein reexpression in tumors. Semin Cnacer Biol 1999; 9: 95-107. https://doi.org/10.1006/scbi.1998.0084
  3. Alpert ME, Uriel J, Nechaud B. Alpha-1 fetoglobulin in the diagnosis of human hepatoma. N Engl J Med 1968; 278: 984-986. https://doi.org/10.1056/NEJM196805022781804
  4. Kitao S, Yamada T, Ishikawa T, Madarame H, Furuichi M, Neo S, Tsuchiya R, Kobayashi K. Alpha-fetoprotein in serum and tumor tissues in dogs with hepatocellular carcinoma. J Vet Diagn Invest 2006;18: 291-295. https://doi.org/10.1177/104063870601800312
  5. Kobayashi K, Sugimoto T, Makino H, Kumagai M, Unoura M, Tanaka N, Kato Y, Hattori N. Screening methods for early detection of hepatocellular carcinoma. Hepatology 1985; 5: 1100-1105. https://doi.org/10.1002/hep.1840050607
  6. Leifer CE, Peterson ME, Matus RE, Patnaik AK. Hypogly-cemia associated with nonislet cell tumor in 13 dogs. J Am Vet Med Assoc 1985; 186: 53-55.
  7. Liptak JM, Dernell WS, Monnet E, Powers BE, Bachand AM, Kenney JG, Withrow SJ. Massive hepatocellular carcinoma in dogs: 48 cases (1992-2002). J Am Vet Med Assoc 2004; 225: 1225-1230. https://doi.org/10.2460/javma.2004.225.1225
  8. Lowseth LA, Gillett NA, Chang IY, Muggenburg BA, Boecker BB. Detection of serum alpha-fetoprotein in dogs with hepatic tumors. J Am Vet Med Assoc 1991; 199: 735-741.
  9. Maluccio MA, Covey AM, Porat LB, Schubert J, Brody LA, Sofocleous CT, Getrajdman GI, Jarnagin W, Dematteo R, Blumgart LH, Fong Y, Brown KT. Transcatheter arterial embolization with only particles for the treatment of unresectable hepatocellular carcinoma. J Vasc Interv Radiol 2007; 19: 862-869.
  10. Magne ML and Withrow SJ. Hepatic neoplasia. 1985 Vet Clin North Am Small Anim Pract 1985; 15: 243-256. https://doi.org/10.1016/S0195-5616(85)50014-5
  11. Okusaka T, Okada S, Ueno H, Ikeda M, Yoshimori M, Shimada K, Yamamoto J, Kosuge T, Yamasaki S, Iwata R, Furukawa H, Moriyama N, Sakamoto M, Hirohashi S. Evaluation of the therapeutic effect of transcatheter arterial embolization for hepatocellular carcinoma. Oncology 2000; 58: 293-9. https://doi.org/10.1159/000012115
  12. Patnaik AK, Hurvitz AI, Lieberman PH. Canine hepatic neoplasms: a clinicopathologic study. Vet Pathol 1980; 17: 553-564. https://doi.org/10.1177/030098588001700504
  13. Patnaik AK, Hurvitz AI, Lieberman PH, Johnson GF. Canine hepatocellular carcinoma. Vet Pathol 1981; 18: 427-438 https://doi.org/10.1177/030098588101800402
  14. Sakai M, Asano K, Nakata M, Takahashi T, Koie H, Yamaya Y, Watari T, Shibuya H, Sato T, Tokuriki M, Hasegawa A. Diabetes mellitus after resection of hepatocellular carcinoma with hypoglycemia in a dog. J Vet Med Sci 2006; 68: 765-767. https://doi.org/10.1292/jvms.68.765
  15. Yamada T, Fusita M, Kitao S, Ashida Y, Nishizono K, Tsuchiya R, Shida T, Kobayashi K. Serum alpha-fetoprotein values in dogs with various hepatic diseases. J Vet Med Sci 1999; 61: 657-656. https://doi.org/10.1292/jvms.61.657