The Journal of the Korea Contents Association (한국콘텐츠학회논문지)

The Korea Contents Association (한국콘텐츠학회)
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Effects of Rotarod Exercise and Electroacupuncture on Muscle Activity and Serum BDNF Level in the Ataxic Rats by the 3-Acetylpyridine

3-Acetylpyridine에 의한 운동실조 동물모델에서 로타로드 운동과 전침이 근활성도와 혈청 BDNF에 미치는 영향

  • 노민희 (부산가톨릭대학교 보건과학대학 물리치료학과) ;
  • 박수경 (부산가톨릭대학교 보건과학대학 물리치료학과)
  • Received : 2009.11.25
  • Accepted : 2010.03.30
  • Published : 2010.04.28
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Abstract

The 3-Acetylpyridine(3-AP) induces cerebellar injury which is chemoablation of the inferior olive nucleus. The purpose of this study was to investigate the effects of exercise(Ex) and electroacupuncture(EA) on muscle activity of hindlimb and serum brain derived neurotrophic factor(BDNF) in the ataxia rats by the 3-AP. 12-week-aged male Sprague-Dawley rats were randomly divided into the 5 groups: Control, 3-AP, 3-AP+Ex, 3-AP+EA and 3-AP+Ex+EA groups. Maximal Height Vertical Jump(MHVJ) was significantly decreased in the 3-AP compared with control group, and it was increased in Ex, EA and Ex+EA groups than 3-AP group. The muscle activity of hindlimb was significantly increased in the 3-AP groups than control group, also it was most decreased in Ex+EA group. The concentration of BDNF of the serum was significantly decreased in the Ex, EA and Ex+EA groups than 3-AP group. The results of this study showed that dynamic exercise and electroacupuncture have a positive effect on functional recovery and in the ataxia rats by the 3-AP.

3-Acetylpyridine(3-AP)는 아래올리브핵을 선택적으로 파괴함으로써, 소뇌 손상을 유발하는 신경독소이다. 본 연구에서는 3-AP의 투여로 운동실조가 유발된 동물모델에서 로타로드 운동과 전침이 후지의 근활성도와 혈청 BDNF에 미치는 영향을 알아보고자 하였다. 본 연구를 위해 실험동물을 대조군, 3-AP군, 운동군, 전침군 그리고 운동전침군으로 무작위 배치하였다. 3-AP군의 최대점핑수직높이는 대조군에 비해 유의하게 감소하였고, 로타로드 운동과 전침의 적용 이후 점차 증가하는 것으로 나타났다. 또한 후지의 근활성도는 3-AP의 투여로 유의하게 증가하였고, 치료적 중재 이후 약간의 감소를 보였다. 3-AP군의 혈청 BDNF 농도는 대조군보다 유의하게 증가하였고, 운동군, 전침군 그리고 운동전침군에서는 3-AP군보다 감소하는 것으로 나타났다. 이러한 결과를 통해 로타로드 운동과 전침은 운동실조 동물모델의 기능적 회복에 긍정적인 치료효과를 가지는 것으로 생각된다.

Keywords

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