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http://dx.doi.org/10.5392/JKCA.2010.10.4.236

Effects of Rotarod Exercise and Electroacupuncture on Muscle Activity and Serum BDNF Level in the Ataxic Rats by the 3-Acetylpyridine  

Rho, Min-Hee (부산가톨릭대학교 보건과학대학 물리치료학과)
Park, Sook-Young (부산가톨릭대학교 보건과학대학 물리치료학과)
Publication Information
The Journal of the Korea Contents Association / v.10, no.4, 2010 , pp. 236-246 More about this Journal
Abstract
The 3-Acetylpyridine(3-AP) induces cerebellar injury which is chemoablation of the inferior olive nucleus. The purpose of this study was to investigate the effects of exercise(Ex) and electroacupuncture(EA) on muscle activity of hindlimb and serum brain derived neurotrophic factor(BDNF) in the ataxia rats by the 3-AP. 12-week-aged male Sprague-Dawley rats were randomly divided into the 5 groups: Control, 3-AP, 3-AP+Ex, 3-AP+EA and 3-AP+Ex+EA groups. Maximal Height Vertical Jump(MHVJ) was significantly decreased in the 3-AP compared with control group, and it was increased in Ex, EA and Ex+EA groups than 3-AP group. The muscle activity of hindlimb was significantly increased in the 3-AP groups than control group, also it was most decreased in Ex+EA group. The concentration of BDNF of the serum was significantly decreased in the Ex, EA and Ex+EA groups than 3-AP group. The results of this study showed that dynamic exercise and electroacupuncture have a positive effect on functional recovery and in the ataxia rats by the 3-AP.
Keywords
3-Acetylpyridine; Ataxia; Rotarod Exercise; Electroacupuncture; Muscle Activity; BDNF;
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