Acute Toxicity Study on Taeeumjowi-tang in Mice

태음조위탕(太陰調胃湯) 추출액이 ICR mouse에서의 경구 투여 급성독성에 미치는 영향

  • Ma, Jin-Yeul (TKM Converging Research Division, Korea Institute of Oriental Medicine) ;
  • Huang, Dae-Sun (Standard Research Division, Korea Institute of Oriental Medicine) ;
  • Seo, Chang-Seob (Standard Research Division, Korea Institute of Oriental Medicine) ;
  • Lee, Si-Woo (Constitutional Medicine Research Division, Korea Institute of Oriental Medicine) ;
  • Kim, Jong-Yeol (Constitutional Medicine Research Division, Korea Institute of Oriental Medicine) ;
  • Shin, Hyeun-Kyoo (Standard Research Division, Korea Institute of Oriental Medicine)
  • 마진열 (한국한의학연구원 한의융합연구본부) ;
  • 황대선 (한국한의학연구원 표준화연구본부) ;
  • 서창섭 (한국한의학연구원 표준화연구본부) ;
  • 이시우 (한국한의학연구원 체질의학연구본부) ;
  • 김종열 (한국한의학연구원 체질의학연구본부) ;
  • 신현규 (한국한의학연구원 표준화연구본부)
  • Received : 2009.10.05
  • Accepted : 2009.11.29
  • Published : 2010.06.30

Abstract

1. Objectives: The aim of this study is to investigate the acute toxicity and safety of Taeeumjowi-tang. 2. Methods: We investigated the acute toxicity for water-extracted Taeeumjowi-tang. 25 male and 25 female mice were observed for 14 days after one day oral administration of Taeeumjowi-tang at the respective doses of 0(control group), 2560, 3200, 4000 and 5000 mg/kg. 3. Results: We observed survival rates, general toxicity, change of body weight and autopsy. 4. Conclusions: The data confirmed that Taeeumjowi-tang is free from the toxicity and safety problems in oral route respectively. Compared with the control group, we could not find any toxic alteration in all treated groups(2560, 3200, 4000 and 5000 mg/kg). In conclusion, LD50 of Taeeumjowi-tang was over 5000 mg/kg and it is very safe to mice.

Keywords

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