Journal of Sasang Constitutional Medicine (사상체질의학회지)

The Society Of Sasang Constitutional Medicine (사상체질의학회)
권호 표지

Acute Toxicity Study on Taeeumjowi-tang in Mice

태음조위탕(太陰調胃湯) 추출액이 ICR mouse에서의 경구 투여 급성독성에 미치는 영향

  • Ma, Jin-Yeul (TKM Converging Research Division, Korea Institute of Oriental Medicine) ;
  • Huang, Dae-Sun (Standard Research Division, Korea Institute of Oriental Medicine) ;
  • Seo, Chang-Seob (Standard Research Division, Korea Institute of Oriental Medicine) ;
  • Lee, Si-Woo (Constitutional Medicine Research Division, Korea Institute of Oriental Medicine) ;
  • Kim, Jong-Yeol (Constitutional Medicine Research Division, Korea Institute of Oriental Medicine) ;
  • Shin, Hyeun-Kyoo (Standard Research Division, Korea Institute of Oriental Medicine)
  • 마진열 (한국한의학연구원 한의융합연구본부) ;
  • 황대선 (한국한의학연구원 표준화연구본부) ;
  • 서창섭 (한국한의학연구원 표준화연구본부) ;
  • 이시우 (한국한의학연구원 체질의학연구본부) ;
  • 김종열 (한국한의학연구원 체질의학연구본부) ;
  • 신현규 (한국한의학연구원 표준화연구본부)
  • Received : 2009.10.05
  • Accepted : 2009.11.29
  • Published : 2010.06.30
Download PDF
⟨ Previous Next ⟩

Abstract

1. Objectives: The aim of this study is to investigate the acute toxicity and safety of Taeeumjowi-tang. 2. Methods: We investigated the acute toxicity for water-extracted Taeeumjowi-tang. 25 male and 25 female mice were observed for 14 days after one day oral administration of Taeeumjowi-tang at the respective doses of 0(control group), 2560, 3200, 4000 and 5000 mg/kg. 3. Results: We observed survival rates, general toxicity, change of body weight and autopsy. 4. Conclusions: The data confirmed that Taeeumjowi-tang is free from the toxicity and safety problems in oral route respectively. Compared with the control group, we could not find any toxic alteration in all treated groups(2560, 3200, 4000 and 5000 mg/kg). In conclusion, LD50 of Taeeumjowi-tang was over 5000 mg/kg and it is very safe to mice.

Keywords

References

  1. Lee JM. Dongeuisusebowon. Seoul:Yeogang Publishing Co. 1992:243-271.
  2. Shin DJ, Kim DL, Kim SH. The effect of Taeumjowetang and herba ephedrae on the obese mRNA and TNF-$\alpha$ mRNA in obesity-induced rats. J Sasang Constitut Med. 2001;13(1):79-87. (Korean)
  3. Lee JM, Lim YT. Effect of taeeumuoweetang herbal- acupuncture on plasma and liver lipid composition and antioxidative capacity in fat fed high fat diet. Kor J Merdian & Acupoint. 2005;22(2):151-161. (Korean)
  4. Cho SW, Park SS. Effects of Taeyeumjowee-tang on loss in body weight, plasma lipids and UCP I revelation of fated white rats. J Kor Oriental Med. 2004;25(2): 87-97. (Korean)
  5. Yoo JH, Lee EJ, Kwak CK, Sohn EH, Koh BH, Song IB, et al. Clinical trial of herbal formula on weight loss in obese Korean children. Am J Chin Med. 2005;33(5): 713-722. https://doi.org/10.1142/S0192415X0500334X
  6. Song MY. The clinical study about the effect of Chungpaesagan-Tang and Taeumjowui-Tang on the Taeumin obesity after fasting therapy. J Oriental Rehab Med. 1998;18(1):34-56. (Korean)
  7. Lee GJ, Kim KY, Jeon BH. Effects of Thaeyeumjoweetang on the obesity of mouse and induced adipocyte 3T3-L1. Kor J Oriental Physiology & Pathology. 1996; 10(1):88-98. (Korean)
  8. Kim MW, Park SS. Effects of Taeumjowetang on lipid peroxidation by free radicals and oxidative damage of hepatocytes by tert-butyl hydroperoxide. J Sasang Constitut Med. 2001;13(1):51-60. (Korean)
  9. Yoon JH, Ryu SH, Chung KH, Choi DG, Jeong IG, Lee HH, et al. Effects of Taeyeumjoweetang and exercise administration on enzymes and fat accumulation of the liver tissue in rats. Kor Society of Exercise Physiology. 2002;11(1):53-65. (Korean)
  10. Yoon JH, Ryu SH, Chung KH, Choi DG, Jeong IG, Lee HH, et al. Effects of 12 weeks Taeyeumjoweetang administration on enzymes and fat accumulation in rat liver cells. Kor Society of Exercise Physiology. 2002;11(2):345-357. (Korean)
  11. Ma JY, Yu YB, Ha HK, Huang DS, Ma CJ, Shin HK. Acute toxicity study on Samul-tang(Siwu-tang) in mice. Kor J Oriental Medical Prescription. 2007; 15(2):113-117. (Korean)
  12. Ma JY, Huang DS, Lee NH, Ha HK, Yu YB, Shin HK. Acute toxicity study on Sipjeondaebo-tang in rats. Kor J Oriental Physiology and Pathology. 2008;22(5): 1192-1195. (Korean)
  13. Ma JY, Huang DS, Yu YB, Ha HK, Shin HK. Acute toxicity study on Palmul-tang(Bawu-tang) in mice. Kor J Herbology. 2007;22(2):13-16. (Korean)
  14. Ma JY, Yu YB, Ha HK, Huang DS, Shin HK. Subacute toxicity study of Sagunja-tang(sijunzi-tang) in SD rats. Kor J Oriental Med. 2007;13(3):151-156. (Korean)
  15. Ma JY, Yu YB, Ha HK, Huang DS, Shin HK. Subacute toxicity study on Palmultang(Bawu-Tang) in SD rats. Kor J Herbology. 2007;22(4):59-64. (Korean)
  16. Ma JY, Huang DS, Lee SW, Kim JY, Shin HK. Acute toxicity study on Yeoldahanso-tang in mice. J Sasang Constitut Med. 2009;21(1):247-253. (Korean)