동의신경정신과학회지 (Journal of Oriental Neuropsychiatry)

  • 제21권2호
  • /
  • Pages.103-123
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  • 2010
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  • 1226-6396(pISSN)
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  • 2234-4942(eISSN)
대한한방신경정신과학회 (The Korean Society of Oriental Neuropsychiatry)
권호 표지

천왕보심단(天王補心丹), 온담탕(溫膽湯), 귀비탕(歸脾湯)이 멜라토닌 수용체 발현에 미치는 영향

Effects of Tianwangbuxin-dan, Wendan-tang, Guipi-tang on the expression of MT1 and MT2 melatonin receptors in C6 glial cells

  • 조윤송 (동의대학교 한의과 대학원 한방신경정신과학교실) ;
  • 김보경 (동의대학교 한의과 대학원 한방신경정신과학교실)
  • Cho, Yun-Song (Dept. of Neuropsychiatry, Undergraduate school of Oriental Medicine, Dong-Eui University) ;
  • Kim, Bo-Kyung (Dept. of Neuropsychiatry, Undergraduate school of Oriental Medicine, Dong-Eui University)
  • 투고 : 2010.05.14
  • 심사 : 2010.06.03
  • 발행 : 2010.06.30
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초록

Objectives : This study was to investigate the effect of several herbal prescriptions such as Tianwangbuxindan qu zhusha, Tianwangbuxindan, Wendantang, Guipitang on the level of $MT_1$ and $MT_2$ melatonin receptors in C6 glial cells. Methods : For this study, we exposed of C6 cells to several herbal prescriptions resulted in non-cytotoxic in various dose as measured by MTT assay, trypan blue count, morphology change and DAPI stain. Results : Tianwangbuxindan qu zhush and Tianwangbuxindan induced the levels of $MT_1$ melatonin receptor expression in a dose-dependent manner without altering the level of $MT_2$ melatonin receptor expression. However, the treatment with Wendantang, Guipitang don't effect of $MT_1$ and $MT_2$ melatonin receptor expression. Conclusions : This results suggest that Tianwangbuxindan can be a promising the regulation of melatonin receptor synthesis, and further studies will be needed to clarify the mechanism.

키워드

참고문헌

  1. 양진향, 김시자, 황미순. 성인환자의 입원전․ 후 수면양상과 수면장애요인. 仁濟論叢. 2005; 20(1):62-646.
  2. Morrey KM, Mclachian JA and Bakouche O. Activation of human monocytes by the pineal hormone melatonin. J. Immunol. 1994;153: 2671-80.
  3. Folkard S, Hume KI, Minors DS, Waterhouse JM and Watson FL. Independence of circardian rhythm in alertness from the sleep-wake cycle. Nature. 1985;313:678-9. https://doi.org/10.1038/313678a0
  4. Arendt J. Melatonin. Clin Endocrinol. 1988; 29:205-29. https://doi.org/10.1111/j.1365-2265.1988.tb00263.x
  5. Frisch H, Parth K, Shobber E and W. Swoboda. Circardian patterns of plasma cortisol 17- hydroxyprogesterone and testosterone in congenital adrenal hyperplasma. Arch. Disea Childhood. 1981;56:208-13. https://doi.org/10.1136/adc.56.3.208
  6. Lissoni P, Barni S and Maestroni GJ. Immunotherapy with subcutaneous low-dose interleukin-2 and pineal indole melatonin as a new effective therapy in advanced cancers of digestive tract. British J. Cancer. 1993;67: 1404-07. https://doi.org/10.1038/bjc.1993.260
  7. Gutteridge JMC. Aging and free radicals. Med. Lab. Sci. 1992;49:313-8.
  8. Felton G. Body rhythm effects on rotation shift work. Nursing Digest. 1976;4:29-32.
  9. Ramsey GM. Basic Pathophysiology - modern stress and the disease process. California: Addison - Wesley. 1982.
  10. Taub JM. Aute shifts in the sleep-wakefulness cycle ; Effects on performance and mood. Psychosoma Med. 1974;36:164-73.
  11. 김인구, 김중한. 黃帝內經에 나타난 불면의 원인에 관한 考察. 大韓韓醫 學原典學會誌. 2005;13(1):57-66.
  12. 李梴. 醫學入門. 서울:南山堂. 1985:3권 239-40.
  13. 林琴. 類證治裁. 臺北:旋風出版社. 1979:257-8.
  14. 許浚.東醫寶鑑. 서울:南山堂. 1974:116-7.
  15. 楊維傑. 黃帝內經靈樞解釋. 서울:一中社. 1991: 127, 252, 256, 266, 271-72, 290, 346-7, 351-2, 450, 488-9, 607.
  16. 王燾. 外臺秘要. 北京:人民衛生出版社. 1982: 91-2, 481-3, 1087, 1088, 1090, 1093-7, 1099, 1106, 1110, 1111.
  17. 張仲景. 仲景全書. 서울:大星文化社. 1984:357.
  18. 張介賓. 類經圖翼. 서울:成輔社. 1982:170-1, 174, 187-8, 191-2, 201, 206, 208-9, 222, 233, 262-5, 273, 286-7, 311.
  19. 趙佶. 聖濟總錄. 北京:人民衛生出版社. 1992.
  20. 대한한방신경정신과학회편. 한방신경정신의학. 집문당. 2005:242-6, 630-41.
  21. 김남재, 공수윤, 장순욱. 天王補心丹이 중추 신경계 및 순환기계에 미치는 영향. 생약학회지. 1988;19(3):208-15.
  22. 김지혁. 天王補心丹 加減方의 抗스트레스 效果에 關한 實驗的 硏究. 慶熙學會. 1988;4(4): 453-66.
  23. 박종흠. 天王補心丹의 항우울효과 및 monoamine 대사에 미치는 영향. 동국대학교 대학원. 2004.
  24. 전국한의과대학 본초학교수 공편저. 本草學. 서울:영림사. 2000:489-90.
  25. 김창덕, 서성훈, 김수억. 溫膽湯 수성엑기스의 中樞抑制作用에 관한 硏究. 경희약대논문집. 1981;9:53-8.
  26. 이동건, 이봉교. 歸脾湯加熟地黃이 생쥐의 睡 眠時間 鎭靜 및 鎭痛作用에 미치는 影響. 동서의학. 1987;12(2):5-16.
  27. 오상훈. 歸脾湯의 五志相勝爲治效果에 關한 實驗的 硏究. 高凰論集. 1988;3:235-60.
  28. 김보라미. 수종의 한약재 열수추출물이 멜라 토닌 수용체 발현에 미치는 영향. 동의신경정신과학회지. 2007;18(1):15-36.
  29. 송윤미. 불면증의 치료. 가정의학회지. 2001; 22(8):1163-72.
  30. 巢元方. 巢氏諸病源候論, 臺北:集中書局. 1977: 36, 90, 217, 226.
  31. 宋太宗命選. 太平聖惠方. 서울:翰成社. 1979:78, 79.
  32. 龔廷. 萬病回春. 서울:杏林書院. 1972:234.
  33. 陳士鐸. 石室秘錄. 서울:杏林書院. 1973:13, 48, 49.
  34. 황의완, 김지혁. 東醫精神醫學. 서울:現代醫學 書籍社. 1992:671-91, 683-9.
  35. 許浚. 東醫寶鑑. 경남 하동:동의보감출판사. 2005:99, 116, 155.
  36. 일심제약 일심만옥단, 한풍제약 순심, (주)제일한방 금왕심단.
  37. Kozier B and Erb G. Fundamental of nursing concepts & procedure. California:Eddison- Wesley Publishing Company. 1983.
  38. 김신미, 오진주, 송미순. 한국노인의 수면양 상과 관련요인에 대한 연구. 간호학논문집. 1997;11:24-38.
  39. Webb, W. B. Theories of sleep functions and someclinical implications In ; The Funtion of Sleep. edited by R. Drucker-Colin, M, Shkurovich and M.B. N.Y:Sterman Academic Press. 1979:19-35.
  40. Lawrence J. Epstein, M.D. 박용한․신윤경 釋. 수면건강과 수면장애. 조윤커뮤니케이션. 2008:31-38, 40.
  41. Axelrod JR and Snyder SH. control of hydroxyindole-O-methyltransferse activity in the rat by environmental lighting. J. Biol. Chem. 1965;240:949-54.
  42. Duvocovich ML and Takahashi JS. Use of 20-[125 I] iodomelatonin bindindg sites in the brain of the Atlantic salmon. salmosalar L. Neuroendocrinology. 1992;55:29-37.
  43. Reppert SM, Godson C, Mahle CD, Weaver DR, Slaugenhaupt SA and Gusella JF. Molecular characterization of a second melatonin receptor expressed in human retina and brain ; the Mel(1b) melatonin receptor. Proc Natl. Acad. Sci. 1995;92:8734-8. https://doi.org/10.1073/pnas.92.19.8734
  44. Weaver DR, Liu C and Reppert SM. Nature's knockout ; The Mel(1b) receptor is not necessary for reproductive and circadian responses to melatonin in Siberian hamsters. Mol. Endocrinol. 1996;10:1478-87. https://doi.org/10.1210/me.10.11.1478
  45. Klein DC. The pineal gland ; A model of neuroenclocrine regulation In ; Rejchlin S, Baldessarini RJ, Martin JB, eds. The Hypothalamus. New york Raven. 1978;6:303.
  46. Brown GM. Light, melatonin and the sleep -wake cycle. J Psychiatry Neurosci. 1994;19: 345.
  47. Lewy J, Sack RL and Blood ML. Melatonin marks circadian phase position and resets the endogenous circadian pacemaker in humans. Cli. Found Sym. 1995;183:303.
  48. Dolberg OT, Hirschmann S and Grunhaus L. melatonin for the treatment of sleep disturbances in major despressive disorder. Am. J. Psychiatry. 1988;155(8):1119.
  49. Ancoli-Israel S, Kripke DF, Mason W and Kaplan OJ. Sleep apnea and Periodic movement in the aging sample. J. Gerontol. 1985;40:419-25. https://doi.org/10.1093/geronj/40.4.419
  50. Kryger MH, Roth T and Dement WC. Principles and Practice of Sleep Medicine. 2nd Ed, WB Saunders. Philadelpia. 1994.
  51. 최소현, 김인, 서광윤. 서울거주 일반성인의 수면 양상에 관한 연구. 신경정신의학. 1992; 32:289-310.
  52. 양창국, M.D. 불면증의 약물치료. 생물치료정신의학. 1997;3(2):103-17.
  53. Roth T, Roehrs T and Zorick F. Determinants in adverse effects of hypnotics In ; Biological Psychitry. Ed by Shagass C. Amsterdam: Elsevier. 1986.
  54. Roth T, Roehrs T. Determinants of residual effects of hypnotics. Accid Anal Prev. 1985; 17:291-6. https://doi.org/10.1016/0001-4575(85)90029-6
  55. Coleman RM. Wide Awake at 3:00 A.M. W.H. Freeman and Company. N.Y. 1986.
  56. 김인, 최윤경, 서광윤. 서울거주 일반인의 수면 위생에 대한 인식과 실행. 신경정신의학. 1997;36:712-21.
  57. Masana MI, Soares JM Jr and Dubocovich ML. $17{\beta}$-estradial modulates hMT1 melatonin receptor function. Neuroendocrinology. 2005; 81:87-95. https://doi.org/10.1159/000084897
  58. Soares JM Jr, Masana MI, Ersahin C and Dubocovich ML. Functional melatonin recepter in rat ovaries at various stages of the estrous cycle. J. pharmacol. Exp. Ther., 2003;306:694-702. https://doi.org/10.1124/jpet.103.049916