Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Development of Worm-like Polymeric Drug Carriers with Multiple Ligands for Targeting Heterogeneous Breast Cancer Cells

  • Lee, A-Hyeong (Division of Biotechnology, The Catholic University of Korea) ;
  • Oh, Kyung-Taek (College of Pharmacy, Chung-Ang University) ;
  • Baik, Hye-Jung (Division of Biotechnology, The Catholic University of Korea) ;
  • Lee, Bo-Reum (Division of Biotechnology, The Catholic University of Korea) ;
  • Oh, Young-Taik (Department of Diagnostic Radiology, Yonsei University College of Medicine) ;
  • Lee, Don-Haeng (Department of Internal Medicine, Inha University) ;
  • Lee, Eun-Seong (Division of Biotechnology, The Catholic University of Korea)
  • Received : 2010.04.13
  • Accepted : 2010.06.17
  • Published : 2010.08.20
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Abstract

In this study, wormorm-like polymeric micelles were construted from poly(L-lactic acid)-b-poly(ethyelen glycol) (PLLA-b-PEG) block copolymers via worm-like (or cylindrical) self- assembly that consisted of a relatively long PLLA block ($M_n$ 7K Daltons) at the core and a relatively short PEG block ($M_n$ 2K Daltons) as the shell. Several cancer-targeting moieties (such as folate, cobalamin, and cyclic arginine-glycine-aspartic (RGD) peptide) were chemically coupled with the succinylated or maleimided PEG block of PLLA-b-PEG to act as a cancer cell-specific targeting ligand for breast cancer. The worm-like micelles with muplite cancer cell-specific ligands proved to be successful in recognizing different breast cancer cells at once. This has the potential to aid in cancer-specific drug delivery and to be used as an effective treatment for breast cancer.

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References

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