Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Effect of Myricetin in Osteoclast Differentiation and Bone Resorption

파골세포 분화와 골 흡수에 myricetin의 효과

  • Lee, An-Saeng (Wonkwang University Hospital) ;
  • Jang, Sung-Jo (Department of Neurosurgery, School of Medicine, Wonkwang University)
  • 이안생 (원광대학교 병원) ;
  • 장성조 (원광대학교 의과대학 신경외과학교실)
  • Received : 2010.01.15
  • Accepted : 2010.02.08
  • Published : 2010.02.25
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Abstract

Osteoclasts are bone-resorbing giant cells that differentiate from hematopoietic cells of the monocyte/macrophages. Excessive osteoclast differentiation leads to gradual loss of bone mass causing fracture of the skeleton. The aim of this study was to develop a drug candidates for the treatment of osteoporosis. RANKL-induced osteoclast differentiation was dose-dependently inhibited by myricetin. Myricetin inhibited the expression of c-Fos, NFATc1, and TRAP in BMMs treated with RANKL. Myricetin disrupted the structure of actin ring and suppressed osteoclastic bone resorption. Also, myricetin induced apoptosis in mature osteoclasts. Myricetin inhibited the phosphorylation of ERK in mature osteoclasts treated with M-CSF. The activation of caspase-9 and caspase-3 was increased by myricetin treatment. Our results suggest that myricetin may be an effective agent to prevent bone diseases such as osteoporosis.

Keywords

References

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