Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Effect of Artemisiae Argi Folium Fermented with Sacchromyces Cerevisiae on Viability of Human Hepatocyte Treated with Toxicants

EtOH 등의 독성물질에 대한 효모균발효애엽 추출물의 간세포보호효과

  • Park, Wan-Su (Department of Pathology, College of Oriental Medicine, Kyungwon University)
  • 박완수 (경원대학교 한의과대학 병리학교실)
  • Received : 2010.02.19
  • Accepted : 2010.03.31
  • Published : 2010.04.25
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Abstract

The purpose of this study is to investigate the effect of water extract from Artemisiae Argi Folium Fermented with Sacchromyces cerevisiae (AFS) on viability of human hepatocyte HepG2 cells treated with hepatotoxicants such as EtOH, gallic acid, nicotine, acetaminophen, acetaldehyde, and lipopolysaccharide. AFS (0~400 ug/mL) was treated with EtOH, gallic acid, nicotine, acetaminophen, acetaldehyde, and lipopolysaccharide. And the viability of HepG2 cells was measured by MTT assay. AFS showed to increase significantly viabilities of HepG2 cells compared with hepatotoxicants (EtOH, gallic acid, nicotine, acetaminophen, and lipopolysaccharide) only (p<0.05). AFS could be supposed to have the hepatoprotective effect against hepatotoxicants such as gallic acid, EtOH, nicotine, acetaminophen, and lipopolysaccharide.

Keywords

References

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