Journal of the Korean Wood Science and Technology

  • 제38권2호
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  • Pages.159-164
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  • 2010
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  • 1017-0715(pISSN)
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  • 2233-7180(eISSN)
한국목재공학회 (The Korean Society of Wood Science & Technology)
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Aldose Reductase Inhibition Effect of PhenolicvCompounds Isolated from Paulownia coreana Bark

  • Kim, Jin-Kyu (Institute of Natural Medicine, Hallym University) ;
  • Lee, Yeon-Sil (Center for Efficacy Assessment and Development of Functional Foods and Drugs, Hallym University) ;
  • Lim, Soon-Sung (Institute of Natural Medicine, Hallym University) ;
  • Bae, Young-Soo (Department of Forest Biomaterials Engineering, Kangwon National University)
  • 투고 : 2010.03.08
  • 심사 : 2010.03.23
  • 발행 : 2010.03.25
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초록

Nine compounds, caffeic acid, naringenin, apigenin, luteolin, kaempferol, verbascoside, isoverbascoside, isocampneoside II, and cistanoside F, were isolated from the EtOAc and n-BuOH fractions of P. coreana bark. The structures of these compounds (1-9) were elucidated by spectroscopic methods and literature data. All the isolates were subjected to in vitro bioassay to evaluate their inhibitory activity against rat lens aldose reductase. Among these, compounds 6 and 8 indicated the significant inhibitory activity on rat lens aldose reductase with $IC_{50}$ values of 2.67 and 5.59 ${\mu}M$, respectively. Especially, The inhibition activity of acteoside was 3.9 times better than that of quercetin as a positive control (10.6 ${\mu}M$). These results suggested that phenylethanoid glycosides are likely to be the potential compounds for the prevention and/or treatment of diabetic complications.

키워드

참고문헌

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피인용 문헌

  1. Pharmacologically tested aldose reductase inhibitors isolated from plant sources — A concise report vol.10, pp.5, 2012, https://doi.org/10.1016/S1875-5364(12)60078-8