Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Decreased Levels of Plasma Testosterone/LH Ratio in Male Mice Exposed to Sodium Arsenite

  • Chang, Soo-Im (College of Veterinary Medicine, Seoul National University) ;
  • Kim, Soo-Hee (College of Veterinary Medicine, Seoul National University) ;
  • Park, Jung-Duck (College of Medicine, Chung-Ang University) ;
  • Ryu, Doug-Young (College of Veterinary Medicine, Seoul National University)
  • Received : 2010.05.13
  • Accepted : 2010.06.29
  • Published : 2010.07.31
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Abstract

While it's been shown that arsenic impairs male reproductive function, it remains unclear whether the mechanism involves an effect on testosterone (T) production. We examined plasma T and luteinizing hormone (LH) levels in mice given water containing either 20 or 40 mg/L sodium arsenite (SA). The plasma T levels were lower in SA-treated mice than in controls and correlated well with testicular T levels within individuals. However, SA treatment did not significantly affect plasma LH levels. The ratio of plasma T to LH was reduced by the treatment with 40 mg/L SA. These results suggest arsenic-induced defect in testicular testosterone production in mice.

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References

  1. Bartke, A. and Dalterio, S. (1975). Evidence for episodic secretion of testosterone in laboratory mice. Steroids 26, 749-756. https://doi.org/10.1016/0039-128X(75)90107-5
  2. Bartke, A., Steele, R. E., Musto, N. and Caldwell, B. V. (1973).Fluctuations in plasma testosterone levels in adult male rats and mice. Endocrinology 92, 1223-1228. https://doi.org/10.1210/endo-92-4-1223
  3. Chang, S. I., Jin, B., Youn, P., Park, C., Park, J. D. and Ryu, D.Y. (2007). Arsenic-induced toxicity and the protective role of ascorbic acid in mouse testis. Toxicol. Appl. Pharmacol. 218, 196-203. https://doi.org/10.1016/j.taap.2006.11.009
  4. Egeland, G. M., Sweeney, M. H., Fingerhut, M. A., Wille, K. K.,Schnorr, T. M. and Halperin, W. E. (1994). Total serum testosterone and gonadotropins in workers exposed to dioxin.Am. J. Epidermiol. 139, 272-281. https://doi.org/10.1093/oxfordjournals.aje.a116994
  5. Foster, W. G., McMahon, A., YoungLai, E. V., Hughes, E. G.and Rice, D. C. (1993). Reproductive endocrine effects of chronic lead exposure in the male cynomolgus monkey. Reprod. Toxicol. 7, 203-209. https://doi.org/10.1016/0890-6238(93)90225-V
  6. Gomendio, M., Malo, A. F., Soler, A. J., Fernandez-Santos, M.R., Esteso, M. C., Garcia, A. J., Roldan, E. R. S. and Garde,J. (2006). Male fertility and sex ratio at birth in red deer.Science 314, 1445-1447. https://doi.org/10.1126/science.1133064
  7. James, W. H. (2006). Possible constraints on adaptive variation in sex ratio at birth in humans and other primates. J. Theor. Biol. 238, 383-394. https://doi.org/10.1016/j.jtbi.2005.05.022
  8. Jana, K., Jana, S. and Samanta, P. K. (2006). Effects of chronic exposure to sodium arsenite on hypothalamo-pituitary-testicular activities in adult rats: possible an estrogenic mode of action. Reprod. Biol. Endocrinol. 4, 9-21. https://doi.org/10.1186/1477-7827-4-9
  9. Jean-Faucher, C., El Watik, N., Berger, M., de Turckheim, M.,Veyssiere, G. and Jean, C. (1983). Ontogeny of the secretory pattern of LH and FSH in male mice during sexual maturation. Int. J. Androl. 6, 575-584. https://doi.org/10.1111/j.1365-2605.1983.tb00348.x
  10. Jeyaraj, D. A., Grossman, G., Petrusz, P. (2005). Altered bioavailability of testosterone in androgen-binding proteintransgenic mice. Steroids 70, 704-714. https://doi.org/10.1016/j.steroids.2005.03.015
  11. Klomberg, K. F., Garland, T. Jr., Swallow, J. G. and Carter, P. A.(2002). Dominance, plasma testosterone levels, and testis size in house mice artificially selected for high activity levels.Physiol. Behav. 77, 27-38. https://doi.org/10.1016/S0031-9384(02)00767-9
  12. Lehmann, K. P., Phillips, S., Sar, M., Foster, P. M. and Gaido, K.W. (2004). Dose-dependent alterations in gene expression and testosterone synthesis in the fetal testes of male rats exposed to Di (n-butyl) phthalate. Toxicol. Sci. 81, 60-68. https://doi.org/10.1093/toxsci/kfh169
  13. Lottrup, G., Andersson, A. M., Leffers, H., Mortensen, G. K.,Toppari, J., Skakkebaek, N. E. and Main, K. M. (2006). Possible impact of phthalates on infant reproductive health. Int. J. Androl. 29, 172-180. https://doi.org/10.1111/j.1365-2605.2005.00642.x
  14. Main, K. M., Mortensen, G. K., Kaleva, M. M., Boisen, K. A.,Damgaard, I. N., Chellakooty, M., Schmidt, I. M., Suomi, A.M., Virtanen, H. E., Petersen, D. V., Andersson, A. M., Toppari,J. and Skakkebaek, N. E. (2006). Human breast milk contamination with phthalates and alterations of endogenous reproductive hormones in infants three months of age.Environ. Health Perspect. 114, 270-276. https://doi.org/10.1289/ehp.8075
  15. Mi, Y., Shapiro, S. D. and Baenziger, J. U. (2002). Regulation of lutropin circulatory half-life by the mannose/N-acetylgalactosamine-4-SO4 receptor is critical for implantation in vivo. J. Clin. Invest. 109, 269-276. https://doi.org/10.1172/JCI13997
  16. Mocarelli, P., Brambilla, P., Gerthoux, P. M., Patterson, D. G. andNeedham, L. L. (1996). Change in sex ratio with exposure to dioxin. Lancet 348, 409. https://doi.org/10.1016/S0140-6736(05)65030-1
  17. Mocarelli, P., Gerthoux, P. M., Ferrari, E., Patterson, D. G.,Kieszak, S. M., Brambilla, P., Vincoli, N., Signorini, S., Tramacere,P., Carreri, V., Sampson, E. J., Turner, W. E. andNeedham, L. L. (2000). Paternal concentrations of dioxin and sex ratio of offspring. Lancet 355, 1858-1863.
  18. Pant, N., Kumar, R., Murthy, R. C. and Srivastava, S. P. (2001).Male reproductive effect of arsenic in mice. Biometals 14,113-117. https://doi.org/10.1023/A:1016686113763
  19. Sarkar, M., Biswas, N. M. and Ghosh, D. (1991). Effect of sodium arsenite on testicular D5-3$\beta$ and 17$\beta$ hydroxysteroid dehydrogenase activation in albino rats: dose and duration dependent response. Med. Sci. Res. 19, 789-790.
  20. Sarkar, M., Chaudhuri, G. R., Chattopadhyay, A. and Biswas, N.M. (2003). Effect of sodium arsenite on spermatogenesis, plasma gonadotrophins and testosterone in rats. Asian J. Androl. 5, 27-31.
  21. Thoreux-Manlay, A., Vélez de la Calle, J. F., Olivier, M. F., Soufir,J. C., Masse, R. and Pinon-Lataillade, G. (1995). Impairment of testicular endocrine function after lead intoxication in the adult rat. Toxicology 100, 101-109. https://doi.org/10.1016/0300-483X(95)03066-O
  22. Yang, Q., Khoury, M. J. and Flanders, W. D. (1997). Sample size requirements in case-only designs to detect geneenvironment interaction. Am. J. Epidemiol. 46, 713-720.

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