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http://dx.doi.org/10.4062/biomolther.2010.18.3.257

Decreased Levels of Plasma Testosterone/LH Ratio in Male Mice Exposed to Sodium Arsenite  

Chang, Soo-Im (College of Veterinary Medicine, Seoul National University)
Kim, Soo-Hee (College of Veterinary Medicine, Seoul National University)
Park, Jung-Duck (College of Medicine, Chung-Ang University)
Ryu, Doug-Young (College of Veterinary Medicine, Seoul National University)
Publication Information
Biomolecules & Therapeutics / v.18, no.3, 2010 , pp. 257-261 More about this Journal
Abstract
While it's been shown that arsenic impairs male reproductive function, it remains unclear whether the mechanism involves an effect on testosterone (T) production. We examined plasma T and luteinizing hormone (LH) levels in mice given water containing either 20 or 40 mg/L sodium arsenite (SA). The plasma T levels were lower in SA-treated mice than in controls and correlated well with testicular T levels within individuals. However, SA treatment did not significantly affect plasma LH levels. The ratio of plasma T to LH was reduced by the treatment with 40 mg/L SA. These results suggest arsenic-induced defect in testicular testosterone production in mice.
Keywords
Arsenic; Testis; Testosterone; Mouse;
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