생약학회지 (Korean Journal of Pharmacognosy)

  • 제41권2호
  • /
  • Pages.108-114
  • /
  • 2010
  • /
  • 0253-3073(pISSN)
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  • 2288-9299(eISSN)
한국생약학회 (The Korean Society of Pharmacognosy)
권호 표지

IFN-$\gamma$와 LPS로 자극된 쥐의 복강 대식세포에서 구척 메탄올 추출물의 항염증 효과

Anti-inflammatory Effect of MeOH Extract of Cibotium barometz in IFN-$\gamma$ and LPS-stimulated Mouse Peritoneal Macrophage

  • 이지영 (우석대학교 약학대학) ;
  • 고성훈 (우석대학교 약학대학) ;
  • 이용재 (우석대학교 약학대학) ;
  • 이세연 (우석대학교 약학대학) ;
  • 박호준 (우석대학교 약학대학) ;
  • 신태용 (헬스케어기술개발사업단) ;
  • 전훈 (헬스케어기술개발사업단)
  • 투고 : 2010.03.12
  • 심사 : 2010.06.07
  • 발행 : 2010.06.30
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초록

The rhizome of Cibotium barometz has been used for variety of bone disease as a traditional medicine. In the present study, we examined the antioxidant and anti-inflammatory activities of 85% methanol extract of C. barometz. C. barometz exhibited potent scavenging effect on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, superoxide radical and nitric oxide radical. In IFN-$\gamma$/LPS-stimulated mouse peritoneal macrophage model, C. barometz suppressed nitric oxide production and IL-6 secretion dose-dependently. Moreover, C. barometz showed decreased iNOS and COX-2 expression without notable cytotoxicity. These results suggest that C. barometz may be an useful agent as an antioxidant and anti-inflammatory agent.

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