생약학회지 (Korean Journal of Pharmacognosy)

  • 제41권2호
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  • Pages.97-102
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  • 2010
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  • 0253-3073(pISSN)
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  • 2288-9299(eISSN)
한국생약학회 (The Korean Society of Pharmacognosy)
권호 표지

식나무 뿌리에서 분리한 트리테르페노이드계 화합물의 IL-6 저해효과

Inhibition of IL-6 Production in TNF-$\alpha$ Stimulated MG-63 by the Triterpenoids Isolated from Aucuba japonica

  • 투고 : 2010.04.27
  • 심사 : 2010.05.17
  • 발행 : 2010.06.30
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초록

Six triterpenoid compounds, friedelin (1), $3{\alpha}$-hydroxy-2-friedelanone (2), canophyllol (3), oleanolic aldehyde acetate (4), ursolic acid (5), and pachysandiol A (6) were isolated from the methylene chloride soluble fraction of the roots of A. japonica. The chemical structures of compounds 1-6 were determined by the basis of physico-chemical properties and spectroscopic methods such as 1D and 2D NMR. These compounds were isolated from this plant for the first time. For the isolated compounds (1-3), the inhibitory effect of IL-6 production in TNF-$\alpha$ stimulated MG-63 was examined. Among the isolates, $3{\alpha}$-hydroxy-2-friedelanone (2) showed potent inhibitory effect on IL-6 production in TNF-$3{\alpha}$ stimulated MG-63.

키워드

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