The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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A Comparative Study of the Anti-cancer Effects of Smilacis Chinae Rhizoma and Smilacis Glabrae Rhizoma on Stomach Cancer SNU-1 Cells

토복령(土茯苓)의 기원식물별 위암 세포 SNU-1에 대한 항암효과 비교연구

  • Ahn, Han-Kyu (Dept. of Herbology, College of Oriental Medicine, Kyungwon University) ;
  • Han, Hyo-Sang (Dept. of Herbology, College of Oriental Medicine, Kyungwon University) ;
  • Lee, Young-Jong (Dept. of Herbology, College of Oriental Medicine, Kyungwon University)
  • 안한규 (경원대학교 한의과대학 본초학교실) ;
  • 한효상 (경원대학교 한의과대학 본초학교실) ;
  • 이영종 (경원대학교 한의과대학 본초학교실)
  • Received : 2010.02.11
  • Accepted : 2010.03.22
  • Published : 2010.03.30
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Abstract

Objectives : The purpose of this study was to compare the anticancer effects of Smilacis Chinae Rhizoma (SCR) and Smilacis Glabrae Rhizoma (SGR) on stomach cancer SNU-1 cells. Methods : The cell proliferation, apoptosis and cytokine level from the extracts were examined in order to compare the anticancer effects of SCR and SGR on SNU-1 cells. Results : SCR had greater anticancer effects than SGR in terms of the inhibition of cell proliferation and apoptosis in the SNU-1 cells. SCR decreased TGF-$\beta$ and SGR increased IL-2 in SNU-1 cells. SCR decreased more TGF-$\beta$ and increased more TNF-$\alpha$ compared to SGR. Conclusions : There were few significant differences according to the concentration and fraction, but a greater anticancer effect of SCR was shown as compared with SGR.

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References

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