Browse > Article
http://dx.doi.org/10.6116/kjh.2010.25.1.023

A Comparative Study of the Anti-cancer Effects of Smilacis Chinae Rhizoma and Smilacis Glabrae Rhizoma on Stomach Cancer SNU-1 Cells  

Ahn, Han-Kyu (Dept. of Herbology, College of Oriental Medicine, Kyungwon University)
Han, Hyo-Sang (Dept. of Herbology, College of Oriental Medicine, Kyungwon University)
Lee, Young-Jong (Dept. of Herbology, College of Oriental Medicine, Kyungwon University)
Publication Information
The Korea Journal of Herbology / v.25, no.1, 2010 , pp. 23-31 More about this Journal
Abstract
Objectives : The purpose of this study was to compare the anticancer effects of Smilacis Chinae Rhizoma (SCR) and Smilacis Glabrae Rhizoma (SGR) on stomach cancer SNU-1 cells. Methods : The cell proliferation, apoptosis and cytokine level from the extracts were examined in order to compare the anticancer effects of SCR and SGR on SNU-1 cells. Results : SCR had greater anticancer effects than SGR in terms of the inhibition of cell proliferation and apoptosis in the SNU-1 cells. SCR decreased TGF-$\beta$ and SGR increased IL-2 in SNU-1 cells. SCR decreased more TGF-$\beta$ and increased more TNF-$\alpha$ compared to SGR. Conclusions : There were few significant differences according to the concentration and fraction, but a greater anticancer effect of SCR was shown as compared with SGR.
Keywords
Smilax china Linne; Smilax glabra Roxb.; Smilacis Chinae Rhizoma; Smilacis Glabrae Rhizoma; anticancer effects; SNU-1;
Citations & Related Records
연도 인용수 순위
  • Reference
1 金昌種. 病態生理學. 서울 : 癸丑文化社. 1988 : 72-4.
2 Mervyn J, Mary D, Gerald MC. Antitumor activity of 1-naphthol against L1210 leukemia in vivo and enrlich ascites tumor cells in vivo and in vitro. Cancer letters. 1986 ; 33 : 347-54.   DOI   ScienceOn
3 Evans VC. Multple pathways to apoptosis. Cell Biol Int. 1993 ; 17(5) : 461-76.   DOI   ScienceOn
4 Shi L, Nishioka WK, Thng J, Bradbury EM, Litchfield DW, Greenberg AH. Premature p34cdc2 activation required for apoptosis. Science. 1994 ; 263(5150) : 1143-5.   DOI
5 Maiolini R, Masseyeff R. A sandwich method of enzymoimmunoassay. I. Application to rat and human alpha-fetoprotein. J Immunol Methods. 1975 Sep ; 8(3) : 223-34.   DOI   ScienceOn
6 張貴君 主編. 常用中藥鑒定大全. 上海 : 黑龍江科學技術出版社. 1993 : 39, 40.
7 서울대학교 의과대학. 종양학. 서울 : 서울대학교 출판부. 1989 : 1-7.
8 한국의약품수출입협회 한국의약품시험연구소 편. 한약재감별주해. 서울 : 도서출판 대영. 2003 : 456-8.
9 肖培根 主編. 新編中藥志. 北京 : 化學工業出版社. 2002 : 60-5.
10 Fukunaga T, Miura T, Furuta K, Kato A. Hypoglycemic effect of the rhizomes of Smilax glabra in normal and diabetic mice. Biol Pharm Bull. 1997 Jan ; 20(1) : 44-6.   DOI   ScienceOn
11 Lee SE, Ju EM, Kim JH. Free radical scavenging and antioxidant enzyme fortifying activities of extracts from Smilax china root. Exp Mol Med. 2001 Dec 31 ; 33(4) : 263-8.   DOI   ScienceOn
12 Gilman AG, Good LS, Gilman A. The pharmacological basis of therapeutics. 6th ed. New York : Macmillan Co Inc. 1975 : 110-5.
13 Pellegrino MA, Ferrone S, Theofilopoulos AN. Isolation of human T and B lymphocytes by rosette formation with 2-aminoethylisothiquronium bromide (AET)-treated sheep red blood cells with monkey red blood cells. J Immunol Methods. 1976 ; 11(3-4) : 273-9.   DOI   ScienceOn
14 Shu XS, Gao ZH, Yang XL. The anti-inflammation effects of Smilax china ethylacetate extract in rats and mice. Zhongguo Zhong Yao Za Zhi. 2006 Feb ; 31(3) : 239-43.
15 Lee H, Lin JY. Antimutagenic activity of extracts from anticancer drugs in Chinese medicine. Mutat Res. 1988 Feb ; 204(2) : 229-34.   DOI
16 李時珍. 本草綱目. 北京 : 人民衛生出版社. 1982: 1294-6.
17 박인호. Antimicrobial Activity and Composition of Extract from Smilax china Root. 한국식품영양과학회지. 1998 ; 27(4) : 574-84.
18 Iddamaldeniya SS, Thabrew MI, Wickramasinghe SM, Ratnatunge N, Thammitiyagodage MG. A long-term investigation of the anti-hepatocarcinogenic potential of an indigenous medicine comprised of Nigella sativa, Hemidesmus indicus and Smilax glabra. J Carcinog. 2006 May 9 ; 5 : 11.
19 Jiang J, Xu Q. Immunomodulatory activity of the aqueous extract from rhizome of Smilax glabra in the later phase of adjuvant-induced arthritis in rats. J Ethnopharmacol. 2003 Mar ; 85(1) : 53-9.   DOI   ScienceOn
20 許浚. 東醫寶鑑. 서울 : 남산당. 1994 : 729.
21 黃度淵. 方藥合編서울 : 남산당. 1992 : 207.
22 行政院 衛生署 中醫藥委員會 中藥典編輯委員會 編.中華民國中藥典範 1985年版. 臺北 : 達昌印刷有限公司. 1985 : 264-6.
23 日本藥局方解說書編纂委. 第十四改正日本藥局方解說書. 東京: 廣川書店. 2001 : 456-8.
24 식품의약품안전청 고시 제2005-54. 대한약전 8개정 대한약전외한약(생약)규격집. 2005 : 380.
25 唐愼微 撰. 重修政和經史證類備用本草. 北京 : 人民衛生出版社. 1982 : 214, 287.
26 陶弘景 集. 尙志鈞 輯校. 名醫別錄. 北京 : 人民衛生出版社. 1986 : 135.
27 江蘇新醫學院編. 中藥大辭典上冊. 上海 : 上海科學技術出版社. 1979 : 91-3.
28 조선민주주의인민공화국 보건부 약전위원회. 조선민 주주의인민공화국약전 제5판. 평양 : 의학과학출판사. 1996 : 261.
29 國家中醫藥管理局中華本草編委會. 中華本草. 上海 : 上海科學技術出版社. 1999 ; (8) : 157-65.
30 國家藥典委員會編. 中華人民共和國藥典2005年版1部. 北京 : 化學工業出版社. 2005 : 14, 15, 216, 217.
31 Pressley JS, Elgert KD. Post-chemotherapeutic administration of interleukin-12 retards tumor growth and enhances immune cell function: combination therapy using paclitaxel and IL-12. Cancer Invest. 2006 Jun-Jul ; 24(4) : 351-9.   DOI   ScienceOn
32 Gajdusek CM, Luo Z, Mayberg MR. Basic fibroblast growth factor and transforming growth factor beta-1: Synergistic mediators of angiogenesis in vitro. J Cell Physiol. 1993 ; 157 : 133-44.   DOI   ScienceOn
33 Paul WE. Fundamental immunolgy. New York : Raven Press. 1989 : 640-7.
34 Morgan DA et al. Selective in vitro growth of T lymphocytes from normal human bone marrow. Science. 1976 ; 193 : 1007-8.   DOI