Korean Journal of Environmental Biology (환경생물)

Korean Society of Environmental Biology (한국환경생물학회)
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Antiangiogenic Effects of Gold Nanoparticles VEGF-induced Vascular Endothelial Cells

금 나노입자의 VEGF에 의해 유발된 혈관 내피세포의 신생혈관형성 억제 효과

  • Choi, Seung-Hyun (School of Biological Sciences and Biotechnology, Chonnam National University) ;
  • Ryu, Geun-Chang (Department of Optometry and Optic Science, Dongshin University) ;
  • Kim, In-Suk (Department of Optometry of Chodang University) ;
  • Chae, Soo-Chul (Department of Biology, Chonnam National University)
  • 최승현 (전남대학교 생물과학 생명기술학과) ;
  • 유근창 (동신대학교 안경광학과) ;
  • 김인숙 (초당대학교 안경광학과) ;
  • 채수철 (전남대학교 생물학과)
  • Received : 2009.11.09
  • Accepted : 2010.01.26
  • Published : 2010.02.28
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Abstract

Angiogenesis is an important event involved in cell growth and wound healing process. However, the imbalance of growth factors causes diseases, such as ocular, inflammatory diseases. One of treatment of these diseases is to suppress the formation of blood vessels. Function and mechanism of gold nanoparticles (AuNPs) in the formation of blood vessels is not yet proved. Pigment epithelium derived factor (PEDF) is currently being offered anti-angiogenic materials. In this study, we postulated that AuNPs might have the ability to inhibit angiogenesis, the pivotal step in tumor growth, invasion and metastasis. We have demonstrated that AuNPs could inhibit vascular endothelial growth factor (VEGF) induced cell proliferation, angiogenesis in bovine retinal endothelial cells.

신생혈관 형성은 세포의 성장 및 상처 치유 과정에서 중요한 현상이다. 그러나 성장인자의 불균형은 시각 및 면역질환과 같은 다양한 질환을 야기한다. 이러한 질환을 치료하는 방법 중 신생혈관 형성을 억제하는 것이 중요한 방법 중 하나이다. AuNPs의 기능과 기전이 신생혈관 형성에 있어서 아직 밝혀진 바가 없다. 현재 PEDF가 항신생혈관 형성 물질로 제안되고 있다. 본 연구에서 우리는 AuNPs가 BRECs에서 VEGF로 유도된 세포의 증식 및 이동, 신생혈관의 형성을 억제하였고 이는 세포의 성장과 침윤 및 전이와 관련된 신생혈관 형성을 억제한다고 사료된다.

Keywords

References

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