폴리머 (Polymer(Korea))

  • 제34권5호
  • /
  • Pages.442-449
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  • 2010
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  • 0379-153X(pISSN)
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  • 2234-8077(eISSN)
한국고분자학회 (The Polymer Society of Korea)
권호 표지

창상치료용 폴리우레탄 폼의 제조 및 특성연구

Fabrication and Characterization of Polyurethane Foam for Wound Dressing

  • 김원일 (금오공과대학교 고분자공학과) ;
  • 김철주 (금오공과대학교 고분자공학과) ;
  • 김대연 (금오공과대학교 고분자공학과) ;
  • 권오경 (경북대학교병원 일반외과) ;
  • 권오형 (금오공과대학교 고분자공학과)
  • Kim, Won-Il (Department of Polymer Science and Engineering, Kumoh National institute of Technology) ;
  • Kim, Cheol-Joo (Department of Polymer Science and Engineering, Kumoh National institute of Technology) ;
  • Kim, Dae-Yeon (Department of Polymer Science and Engineering, Kumoh National institute of Technology) ;
  • Kwon, Oh-Kyoung (Department of General Surgery, Kyungpook National University Hospital) ;
  • Kwon, Oh-Hyeong (Department of Polymer Science and Engineering, Kumoh National institute of Technology)
  • 투고 : 2010.04.20
  • 심사 : 2010.05.18
  • 발행 : 2010.09.25
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초록

본 연구에서는 hard segment 함량(%)별로 친수성의 폴리우레탄 프리폴리머를 합성한 후 다양한 발포 혼합 조성액을 이용하여 폴리우레탄 폼을 제조하였다. 그 결과 사슬연장제를 도입한 폴리우레탄 프리폴리머가 도입하지 않은 것에 비해 기계적 물성이 우수하였다. 또한 폴리우레탄 구조에 hard segment 함량(%)을 높임으로써 폴리우레탄의 기계적 물성을 향상시킬 수 있었다. 한편 발포 혼합조성액에서도 F-68, 글리세린, CMC 등의 원료 배합비를 조정함으로써 최종적으로 제조된 폴리우레탄 폼의 기계적 물성과 흡수도, 흡수속도, 모폴로지 등을 조절할 수 있었다. 제조된 폴리우레탄 폼은 세포배양 결과 세포적합성이 우수하였고, 동물실험 결과 대조군인 거즈에 비하여 월등한 창상치유 효과를 보였으므로 창상치료용 소재로서의 적용 가능성이 높음을 알 수 있었다.

Polyurethane(PU) prepolymer was synthesized from ethylene oxide/propylene oxide(EO/PO) random polyether polyol, toluene diisocyanate and chain extender such as ethylene glycol and 1,4-butanediol. PU foams having various compositions were fabricated from PU prepolymers with different hard segment contents(%) and mixed foaming solution of different compositions. PU foam from chain extender-introduced PU prepolymer and mixed foaming solution containing glycerin showed better mechanical property than other groups. Various PU foams were tested on their mechanical property, moisture vapor transmission rate, absorption speed, absorptivity, morphology and cell culture test. According to the test, the PU foam fabricated from chain extender-introduced PU prepolymer and mixed foaming solution containing optimum composition of F-68, glycerin and CMC was found to have the best property for wound dressing materials. From in vivo animal study, it was confirmed that above PU foam showed rapid wound recovery.

키워드

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