YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Inhibition of Nitric Oxide Production by Anthraquinones from Polygonum cuspidatum

호장으로부터 분리한 안트라퀴논류의 Nitric Oxide 저해활성

  • Joo, Si-Mong (College of Pharmacy, Sookmyung Women's University) ;
  • Yang, Ki-Sook (College of Pharmacy, Sookmyung Women's University)
  • 주시몽 (숙명여자대학교 약학대학) ;
  • 양기숙 (숙명여자대학교 약학대학)
  • Received : 2010.03.23
  • Accepted : 2010.09.20
  • Published : 2010.10.31
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Abstract

Polygonum cuspidatum which is widely distributed in Korea has been used as treatments of dermatitis, gonorrhea and inflammation in traditional medicine. We examined anti-inflammatory activities by the inhibition of NO production in RAW264.7 murine macrophages cells. Phytochemical examination of Polygonum cuspidatum led to the isolation and characterization of emodin (1), emodin 8-O-${\beta}$-D-glucopyranoside (2), emodin 1-O-${\beta}$-D-glucopyranoside (3). Antioxidative activities of these compounds were determined by measuring the radical scavenging effects on DPPH radicals. Compounds 1 and 3 showed potent activities compared with L-NMMA. These results suggested that the antraquinone compounds isolated from Polygonum cuspidatum might be used as antiinflammatory agents.

Keywords

References

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