약학회지 (YAKHAK HOEJI)

  • 제54권5호
  • /
  • Pages.323-327
  • /
  • 2010
  • /
  • 0377-9556(pISSN)
  • /
  • 2383-9457(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

PC12 세포주에서 Translationally Controlled Tumor Protein에 의한 Mitogen-activated Protein Kinases 활성 조절

Regulation of Mitogen-activated Protein Kinases by Translatoinally Controlled Tumor Protein in PC12 Cells

  • 김미연 (이화여자대학교 약학대학) ;
  • 김미영 (이화여자대학교 약학대학)
  • Kim, Mi-Yeon (College of Pharmacy, Center for Cell Signalling & Drug Discovery Research, Ewha Womans University) ;
  • Kim, Mi-Young (College of Pharmacy, Center for Cell Signalling & Drug Discovery Research, Ewha Womans University)
  • 투고 : 2010.08.30
  • 심사 : 2010.09.16
  • 발행 : 2010.10.31
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Translationally controlled tumor protein (TCTP) activates basophils to release histamine and causes chronic inflammation. It was also reported that TCTP significantly reduced in brain of Alzheimer's Disease and Down Syndrome as compared to normal person, suggesting that TCTP might be involved in cognitive function. We wondered whether TCTP could act as a general inducer in neurotransmitters release in brain. We, therefore, investigated the role of TCTP in PC12 cell line which expressed neuronal properties. We found that TCTP could activate JNK, and the activity was inhibited by pretreatment of dicoumarol, a JNK inhibitor. However, TCTP could not activate ERK that has known to be involved in neurotransmitter release. These suggest TCTP did not participate in neurotransmitter release from PC12 cells, and TCTP might not be a general inducer in neurotransmitter release.

키워드

참고문헌

  1. Warner, J. A., Pienkowski, M. M., Plaut, M., Norman, P. S. and Lichtenstein, L. M. : Identification of histamine releasing factor(s) in the late phase of cutaneous IgE-mediated reactions. J. Immunol. 136, 2583 (1986).
  2. Yoneda, K., Rokutan, K., Nakamura, Y., Yanagawa, H., Kondo- Teshima, S. and Sone, S. : Stimulation of human bronchial epithelial cells by IgE-dependent histamine-releasing factor. Am. J. Physiol. Lung Cell Mol. Physiol. 286, L174 (2004).
  3. MacDonald, S. M., Rafnar, T., Langdon, J. and Lichtenstein, L. M. : Molecular identification of an IgE-dependent histaminereleasing factor. Science 269, 688 (1995). https://doi.org/10.1126/science.7542803
  4. Thueson, D. O., Speck, L. S., Lett-Brown, M. A. and Grant, J. A. : Histamine-releasing activity (HRA). I. Production by mitogen- or antigen-stimulated human mononuclear cells. J. Immunol. 123, 626 (1979).
  5. Sanchez, J. C., Schaller, D., Ravier, F., Golaz, O., Jaccoud, S., Belet, M., Wilkins, M. R., James, R., Deshusses, J. and Hochstrasser, D. : Translationally controlled tumor protein: a protein identified in several nontumoral cells including erythrocytes. Electrophoresis 18, 150 (1997). https://doi.org/10.1002/elps.1150180127
  6. MacDonald, S. M., Lichtenstein, L. M., Proud, D., Plaut, M., Naclerio, R. M., MacGlashan, D. W. and Kagey-Sobotka, A. : Studies of IgE-dependent histamine releasing factors: heterogeneity of IgE. J. Immunol. 139, 506 (1987).
  7. Sampson, H. A., Broadbent, K. R. and Bernhisel-Broadbent, J. : Spontaneous release of histamine from basophils and histamine-releasing factor in patients with atopic dermatitis and food hypersensitivity. N. Engl. J. Med. 321, 228 (1989). https://doi.org/10.1056/NEJM198907273210405
  8. Beaven, M. A. and Baumgartner, R. A. : Downstream signals initiated in mast cells by Fc epsilon RI and other receptors. Curr. Opin. Immunol. 8, 766 (1996). https://doi.org/10.1016/S0952-7915(96)80002-1
  9. MacDonald, S. M. : Human recombinant histamine-releasing factor. Int. Arch. Allergy. Immunol. 113, 187 (1997). https://doi.org/10.1159/000237542
  10. Bheekha-Escura, R., MacGlashan, D. W., Langdon, J. M. and MacDonald, S. M. : Human recombinant histamine-releasing factor activates human eosinophils and the eosinophilic cell line, AML14-3D10. Blood. 96, 2191 (2000).
  11. MacDonald, S. M. : Histamine-releasing factors. Curr. Opin. Immunol. 8, 778 (1996). https://doi.org/10.1016/S0952-7915(96)80004-5
  12. Kang, H. S., Lee, M. J., Song, H., Han, S. H., Kim, Y. M., Im, J. Y. and Choi, I. : Molecular identification of IgE-dependent histamine-releasing factor as a B cell growth factor. J. Immunol. 166, 6545 (2001).
  13. Kim, M., Min, H. J., Won, H. Y., Park, H., Lee, J. C., Park, H. W., Chung, J., Hwang, E. S. and Lee, K. : Dimerization of translationally controlled tumor protein is essential for its cytokine-like activity. PLoS One. 4, e6464 (2009). https://doi.org/10.1371/journal.pone.0006464
  14. Onodera, K., Yamatodani, A., Watanabe, T. and Wada, H. : Neuropharmacology of the histaminergic neuron system in the brain and its relationship with behavioral disorders. Prog. Neurobiol. 42, 685 (1994). https://doi.org/10.1016/0301-0082(94)90017-5
  15. Passani, M. B., Bacciottini, L., Mannaioni, P. F. and Blandina, P. : Central histaminergic system and cognition. Neurosci Biobehav Rev. 24, 107 (2000). https://doi.org/10.1016/S0149-7634(99)00053-6
  16. Schneider, C., Risser, D., Kirchner, L., Kitzmuller, E., Cairns, N., Prast, H., Singewald, N. and Lubec, G. : Similar deficits of central histaminergic system in patients with Down syndrome and Alzheimer disease. Neurosci Lett. 222, 183 (1997). https://doi.org/10.1016/S0304-3940(97)13379-1
  17. Fernandez-Novoa, L. and Cacabelos, R. : Histamine function in brain disorders. Behav Brain Res. 124, 213 (2001). https://doi.org/10.1016/S0166-4328(01)00215-7
  18. Kim, S. H., Cairns, N., Fountoulakisc, M. and Lubec, G. : Decreased brain histamine-releasing factor protein in patients with Down syndrome and Alzheimer's disease. Neurosci Lett. 300, 41 (2001). https://doi.org/10.1016/S0304-3940(01)01545-2
  19. Vonakis, B. M., Macglashan, D. W., Jr., Vilarino, N., Langdon, J. M., Scott, R. S. and MacDonald, S. M. : Distinct characteristics of signal transduction events by histamine-releasing factor/translationally controlled tumor protein (HRF/TCTP)- induced priming and activation of human basophils. Blood. 111, 1789 (2008). https://doi.org/10.1182/blood-2007-07-104364
  20. Rosen, L. B., Ginty, D. D., Weber, M. J. and Greenberg, M. E. : Membrane depolarization and calcium influx stimulate MEK and MAP kinase via activation of Ras. Neuron. 12, 1207 (1994).
  21. Legrand-Poels, S., Maniglia, S., Boelaert, J. R. and Piette, J. : Activation of the transcription factor NF-kappaB in lipopolysaccharide- stimulated U937 cells. Biochem. Pharmacol. 53, 339 (1997). https://doi.org/10.1016/S0006-2952(96)00715-0
  22. Bloch-Shilderman, E., Jiang, H., Abu-Raya, S., Linial, M. and Lazarovici, P. : Involvement of extracellular signal-regulated kinase (ERK) in pardaxin-induced dopamine release from PC12 cells. J. Pharmacol. Exp. Ther. 296, 704 (2001).