Clinical and Experimental Pediatrics

The Korean Pediatric Society (대한소아청소년과학회)
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A case of paraneoplastic limbic encephalitis due to ovarian mature teratoma

성숙 난소기형종에 동반된 부신생물 변연계뇌염 1례

  • Kim, Seong-Heon (Department of Pediatrics, Pusan National University Hospital Pusan National University College of Medicine) ;
  • Kim, Hye-Young (Department of Pediatrics, Pusan National University Hospital Pusan National University College of Medicine) ;
  • Im, Young-Tak (Department of Pediatrics, Pusan National University Hospital Pusan National University College of Medicine) ;
  • Nam, Sang-Ook (Department of Pediatrics, Pusan National University Hospital Pusan National University College of Medicine) ;
  • Kim, Young-Mi (Department of Pediatrics, Pusan National University Hospital Pusan National University College of Medicine)
  • 김성헌 (부산대학교 의학전문대학원 소아과학교실) ;
  • 김혜영 (부산대학교 의학전문대학원 소아과학교실) ;
  • 임영탁 (부산대학교 의학전문대학원 소아과학교실) ;
  • 남상욱 (부산대학교 의학전문대학원 소아과학교실) ;
  • 김영미 (부산대학교 의학전문대학원 소아과학교실)
  • Received : 2009.12.29
  • Accepted : 2010.02.10
  • Published : 2010.04.15
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Abstract

Paraneoplastic limbic encephalitis, a remote effect of cancer without nervous system metastasis, is rare, especially in childhood. Here, we report a case of paraneoplastic limbic encephalitis associated with an ovarian mature teratoma in an adolescent girl. The 15-year-old girl developed neuropsychiatric symptoms, memory loss, seizures, and unconsciousness. Cerebrospinal fluid analysis and brain magnetic resonance imaging (MRI) findings were normal, while single photon emission computed tomography imaging showed hypoperfusion in both temporal lobes. Ultrasound and MRI of the abdomen revealed a left ovarian cystic mass. The patient experienced a significant recovery of cognitive function after surgical resection of the tumor, which was pathologically identified as a mature ovarian teratoma, and treatment with intravenous immunoglobulin.

부신생물 변연계뇌염(paraneoplastic limbic encephalitis)은 신경계의 전이가 없이 종양의 원격 작용에 의해 발생하는 질환으로 소아에서는 드물게 보고되고 있다. 저자들은 사춘기 여아에서 발생한 성숙 난소기형종에 동반된 부신생물 변연뇌염을 경험하고 보고하고자 한다. 15세 여자 환자가 신경정신증상, 기억력 저하, 경련, 의식 저하를 주소로 내원하였다. 뇌척수액 검사, 뇌 MRI는 정상이었으나, 뇌 SPECT 검사에서 양측 측두엽의 저관류가 관찰되었다. 복부 초음파와 MRI에서 좌측 난소의 낭성 종양이 발견되었다. 종양의 수술적 제거 후 성숙 난소기형종으로 확인되었으며, 종양 제거 및 면역글로불린 정맥 투여로 완전한 인지 기능의 회복을 보였다.

Keywords

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