Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Spectrophotometric Determination of Allopurinol Drug in Tablets: Spectroscopic Characterization of the Solid CT Complexes

  • Refat, Moamen S. (Department of Chemistry, Faculty of Science, Port Said 42111, Suez Canal University) ;
  • Mohamed, Gehad G. (Chemistry Department, Faculty of Science, Cairo University) ;
  • Fathi, Ahmed (Chemistry Department, Faculty of Science, Cairo University)
  • Received : 2010.02.11
  • Accepted : 2010.03.31
  • Published : 2010.06.20
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Abstract

Spectrophotometric micro determination of allopurinol (ALP) via charge-transfer formation is described. This includes the utility of some $\pi$-acceptors such as 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) and 3,6-dichloro-2,5-dihydroxy-p-benzoquinone (p-CLA) for estimation of ALP drug (act as $\grave{e}$-donor). These reactions are applied for determination of ALP in its pharmaceutical preparations coming from different companies. Elucidation of the chemical structure of the solid CT complexes formed via reaction between drugs under study and $\pi$-acceptors, using elemental analyses (C, H, N), I. R., $^1H$ NMR and mass spectrometry.

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References

  1. Hardaman, J. G., Limbird, L. E., Eds. The Pharmacological Basis of Therapeuties (Godman & Gilman’s), 10th ed.; McGraw-Hill:New York, 2001; p 721.
  2. Endele, E.; Lettenbaucer, G. J. Chromatogr. 1975, 115, 228. https://doi.org/10.1016/S0021-9673(00)89037-8
  3. Brown, M.; Bye, J. J. Chromatogr. 1977, 143, 195. https://doi.org/10.1016/S0378-4347(00)81824-1
  4. Putterman, G. J.; Shaikh, B.; Hallmark, M. R.; Sawyer, C. G.; Hixson, C. V.; Perini, F. Anal. Biochem. 1979, 98, 18. https://doi.org/10.1016/0003-2697(79)90700-0
  5. Chang, S. L.; Kramer, W. G. J. Chromatogr. 1980, 181, 286. https://doi.org/10.1016/S0378-4347(00)81616-3
  6. Miyazaki, H.; Matsunaga, Y.; Yoshida, K.; Arakawa, S.; Hashimoto, M. J. Chromatogr. Biomed. Appl. 1983, 25, 75.
  7. Boulien, R.; Bory, C.; Baltassat, P.; Gonnet, C. J. Chromatogr. Biomed. Appl. 1984, 307, 469. https://doi.org/10.1016/S0378-4347(00)84124-9
  8. Hung, C. T.; Zoest, A. R.; Perrier, D. G. J. Liq. Chromatogr. 1986, 9, 2471. https://doi.org/10.1080/01483918608076879
  9. Safranow, K.; Machoy, Z.; Ciechanowski, K. Anal. Biochem. 2000, 286, 224. https://doi.org/10.1006/abio.2000.4790
  10. Palmisano, F.; Desimoni, E.; Zambonin, P. G. J. Chromatogr. Biomed. Appl. 1984, 306, 205. https://doi.org/10.1016/S0378-4347(00)80883-X
  11. Eisenberg, E. J.; Conzentino, P.; Liversidge, G. G.; Cundy, K. C. J. Chromatogr. Biomed. Appl. 1990, 95, 65.
  12. Perez-Ruiz, T.; Martinez-Lozano, C.; Tomás, V.; Galera, R. J. Chromatogr. B 2003, 798, 303. https://doi.org/10.1016/j.jchromb.2003.10.002
  13. Sun, X.; Cao, W.; Bai, X.; Yang, X.; Wang, E. Anal. Chim. Acta 2001, 442, 121. https://doi.org/10.1016/S0003-2670(01)01135-7
  14. Wessel, T.; Lanvers, C.; Fruend, S.; Hempel, G. J. Chromatogr. A 2000, 894, 157. https://doi.org/10.1016/S0021-9673(00)00439-8
  15. Breimer, D. D.; Speiser, P. Topics in Pharmaceutical Sciences; Elsevier Science Publishers: 1983.
  16. Kover, K. A.; Mayer, W. Pharm. Uns. Zeit 1979, 8, 1979.
  17. Foster, R. Organic Charge-Transfer Complex; Academic Press:London, 1969; pp 4-23.
  18. Refat, M. S.; Hamdy, A. A.; Grabchev, I.; El-Zayat, L. A. Spectrochimica Acta, Part A 2008, 70, 907. https://doi.org/10.1016/j.saa.2007.10.007
  19. Vosburg, W. C.; Cooper, G. R. J. Am. Chem. Soc. 1941, 63, 437. https://doi.org/10.1021/ja01847a025
  20. British pharmacopeia" Vol. I, 76, 2008.
  21. British pharmacopeia" Vol. I, 89, 2008.
  22. Bellamy, L. J. The Infrared Spectra of Complex Molecules; Chapman & Hall: London, 1975.

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