DOI QR코드

DOI QR Code

Electro-responsive Transdermal Drug Release of MWCNT/PVA Nanocomposite Hydrogels

  • Kim, Yeon-Yi (Department of Fine Chemical Engineering and Applied Chemistry, BK21-E2M, Chungnam National University) ;
  • Yun, Ju-Mi (Department of Fine Chemical Engineering and Applied Chemistry, BK21-E2M, Chungnam National University) ;
  • Lee, Young-Seak (Department of Fine Chemical Engineering and Applied Chemistry, BK21-E2M, Chungnam National University) ;
  • Kim, Hyung-Il (Department of Fine Chemical Engineering and Applied Chemistry, BK21-E2M, Chungnam National University)
  • Received : 2010.06.28
  • Accepted : 2010.09.09
  • Published : 2010.09.30

Abstract

Multi-walled carbon nanotube (MWCNT)/poly(vinyl alcohol) (PVA) nanocomposite hydrogels were prepared by freezingthawing method for the electro-responsive transdermal drug delivery. MWCNTs were used as the functional ingredient to improve both mechanical and electrical properties of MWCNT/PVA nanocomposite hydrogels. The morphology of nanocomposites revealed the uniform distribution of MWCNTs and the good interfacial contact. The compression moduli of hydrogel matrices increased greatly from 40 to 1500 kPa by forming MWCNT/PVA nanocomposites. The swelling ratio of MWCNT/PVA nanocomposites decreased as the content of MWCNTs increased under no electric voltage applied. However, the swelling ratio of MWCNT/PVA nanocomposites increased as the content of MWCNTs increased under electric voltage applied and the applied electric voltage increased. The drug was released in the electro-responsive manner through the skin due to the electro-sensitive swelling characteristics of MWCNT/PVA nanocomposite hydrogels.

Keywords

References

  1. Langer, R. Adv. Drug Delivery Rev. 2004, 56, 557. https://doi.org/10.1016/j.addr.2003.10.021
  2. Prausnitz, M. R.; Mitragotri, S.; Langer, R. Nat. Rev. Drug Discovery 2004, 3, 115. https://doi.org/10.1038/nrd1304
  3. Murdan, S. J. Control. Release 2003, 92, 1. https://doi.org/10.1016/S0168-3659(03)00303-1
  4. Gudeman, L. F.; Peppas, N. A. J. Membr. Sci. 1995, 107, 239. https://doi.org/10.1016/0376-7388(95)00120-7
  5. Xu, F.; Kang, E.; Neoh, K. Biomaterials 2006, 27, 2787. https://doi.org/10.1016/j.biomaterials.2006.01.003
  6. Chien, Y. W.; Lelawong, P.; Siddiqui, O.; Sun, Y.; Shi, W. M. J. Control. Release 1990, 13, 263. https://doi.org/10.1016/0168-3659(90)90017-N
  7. Mohammad, M.; Karen, I. W. Macromolecules 2006, 39, 5194. https://doi.org/10.1021/ma060733p
  8. Daoush, W. M; Lim, B. K.; Mo, C. B; Nam, D. H.; Hong, S. H. Mat. Sci. Eng. A 2009, 513, 247. https://doi.org/10.1016/j.msea.2009.01.073
  9. Miuik, M.; Omastova, M.; Krupa, I.; Proke. J.; Pissis, P.; Logakis, E.; Pandis, C.; Potschke, P.; Pionteck, J. J. Appl. Polym. Sci. 2009, 113, 2536. https://doi.org/10.1002/app.30418
  10. Shen, Z.; Bateman, S.; Wu, D. Y.; McMahon, P.; Dell'Olio, M.; Gotama, J. J. Compos. Sci. Technol. 2009, 69, 239. https://doi.org/10.1016/j.compscitech.2008.10.017
  11. Bianco, A.; Kostarelos, K.; Prato, M. Curr. Opin. Chem. Biol. 2005, 9, 674. https://doi.org/10.1016/j.cbpa.2005.10.005
  12. Davis, J. J.; Coleman, K. S.; Azamian, B. R.; Bagshaw, C. B.; Green, M. L. H. Chem. Eur. J. 2003, 9, 3732. https://doi.org/10.1002/chem.200304872
  13. Scranton, A. B.; Rangarajan, B.; Klier, J. J. Adv. Polym. Sci. 1995, 122, 1. https://doi.org/10.1007/3540587888_13
  14. Bell, C. L.; Peppas, N. A. J. Adv. Polym. Sci. 1995, 122, 126.
  15. Stauffer, S. R.; Peppas, N. A. J. Polym. 1992, 33, 3932. https://doi.org/10.1016/0032-3861(92)90385-A
  16. Hassan, C. M.; Peppas, N. A. J. Adv. Polym. Sci. 2000, 153, 37. https://doi.org/10.1007/3-540-46414-X_2
  17. Oh, A.; Jin, D. H.; Yun, J.; Lee, Y. S.; Kim, H. I. Carbon Letters 2009, 10, 208. https://doi.org/10.5714/CL.2009.10.3.208
  18. Kim, S. Y.; Lee, Y. M. J. Appl. Polym. Sci. 1999, 74, 1752. https://doi.org/10.1002/(SICI)1097-4628(19991114)74:7<1752::AID-APP18>3.0.CO;2-H

Cited by

  1. A review of the preparation and properties of carbon nanotubes-reinforced polymer compositess vol.12, pp.2, 2011, https://doi.org/10.5714/CL.2011.12.2.057