Environmental Analysis Health and Toxicology

환경독성보건학회 (The Korean Society of Environmental Health and Toxicology)
권호 표지

Acute Toxicity Assessment of New Algicides of Thiazolidinediones Derivatives, TD53 and TD49, Using Ulva pertusa Kjellman

  • Yim, Eun-Chae (Collaborate Course of Bioenergy and Biomaterial, Chonnam National University) ;
  • Park, In-Taek (Department of Environmental Engineering, Chonnam National University) ;
  • Han, Hyo-Kyung (College of Pharmacy, Dongguk University) ;
  • Kim, Si-Wouk (Department of Environmental Engineering, Chosun University) ;
  • Cho, Hoon (Department of Polymer Science & Chemical Engineering, Chosun University) ;
  • Kim, Seong-Jun (Department of Environmental Engineering, Chonnam National University)
  • 투고 : 2010.06.14
  • 심사 : 2010.09.17
  • 발행 : 2010.12.31
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초록

Objectives : This study was aimed to examine the acute toxicity assessment of two new algicides, thiazolidinediones derivatives (TD53 and TD49), which were synthesized to selectively control red tide, to the marine ecosystem. Methods : The assessment employed by a new method using Ulva pertusa Kjellman which has been recently accepted as a standard method of ISO. The toxicity was assessed by calculating the $EC_{50}$ (Effective Concentration of 50%), NOEC (No Observed Effect Concentration) and PNEC (Predicted No Effect Concentration) using acute toxicity data obtained from exposure experiments. $EC_{50}$ value of TD49 and TD53 was examined by 96-hrs exposure together with Solutol as a TD49 dispersing agent and DMSO as a TD53 solvent. Results : $EC_{50}$ value of TD53 was $1.65\;{\mu}M$. From the results, values of NOEC and PNEC were calculated to be $0.63\;{\mu}M$ and 1.65 nM, respectively. DMSO under the range of $0{\sim}10\;{\mu}M$, which is same solvent concentration used in examining TD53, showed no toxic effect. $EC_{50}$ value of TD49 was $0.18\;{\mu}M$ and that of Solutol was $1.70\;{\mu}M$. NOEC and PNEC of TD49 were $0.08\;{\mu}M$ and 0.18 nM, respectively and those for Solutol were $1.25\;{\mu}M$ and 1.25 nM, respectively. Conclusions : From the values of NOEC, PNEC of TD53 and TD49, TD49 showed 9 times stronger toxicity than TD53. On the other hand, DMSO showed no toxicity on the Ulva pertusa Kjellman, but Solutol was found to be a considerable toxicity by itself.

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