Comparison of Distribution and Inflammatory Response by Diameter and Shape of Silver Nanoparticles

은나노 입자의 입경 크기 및 형태에 따른 체내 동태 및 염증 반응

  • Kim, Soo-Nam (Inhalation Toxicology Center, KIT Jeongeup Campus) ;
  • Roh, Jin-Kyu (Department of Chemical Engineering, Kwangwoon University) ;
  • Kang, Min-Sung (Inhalation Toxicology Center, KIT Jeongeup Campus) ;
  • Han, Young-Ah (Inhalation Toxicology Center, KIT Jeongeup Campus) ;
  • Lee, Byoung-Seok (Division of Toxicologic Pathology, Korea Institute of Toxicology) ;
  • Kim, Young-Hun (Department of Chemical Engineering, Kwangwoon University) ;
  • Park, Kwang-Sik (College of Pharmacy, Dongduk Women's University) ;
  • Choi, Kyung-Hee (Department of Risk Assessment, National Institute of Environmental Research) ;
  • Park, Eun-Jung (Department of Risk Assessment, National Institute of Environmental Research)
  • 김수남 (한국화학연구원 부설 안전성평가연구소 정읍분소 흡입독성시험연구센터) ;
  • 노진규 (광운대학교 공과대학 화학공학과) ;
  • 강민성 (한국화학연구원 부설 안전성평가연구소 정읍분소 흡입독성시험연구센터) ;
  • 한영아 (한국화학연구원 부설 안전성평가연구소 정읍분소 흡입독성시험연구센터) ;
  • 이병석 (한국화학연구원 부설 안전성평가연구소 대전본소 독성병리부) ;
  • 김영훈 (광운대학교 공과대학 화학공학과) ;
  • 박광식 (동덕여자대학교 약학대학 예방약학교실) ;
  • 최경희 (국립환경과학원 환경건강연구부 위해성평가연구과) ;
  • 박은정 (국립환경과학원 환경건강연구부 위해성평가연구과)
  • Received : 2010.04.22
  • Accepted : 2010.09.02
  • Published : 2010.09.30

Abstract

The market size of engineered nanoparticles is rapidly increasing due to the fast application of nanotechnologies into different industries and consumer products. The development of new technology and materials has improved human's quality of life, but it also entails the possibility of exposure to new materials. In this study, we compared the distribution in the body by the inflow of silver nanoparticles having another diameter and shape at 1 h or 24 h after injection via the tail vein. And, we compared the cell composition and cytokine concentration in BAL fluid, and histopathological changes. As results, discharge of silver nanoparticles having small diameter and sphere shape was more rapid than that of big diameter or plate shape. It is estimated that the toxicity in liver and lung was proportional to accumulation level. The persistence of inflammation was also longer in mice treated with plate shape. Consequently, we suggest that the first choice of silver nanoparticles having small diameter and sphere shape in applying is desirable.

Keywords

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