Bulletin of the Korean Chemical Society

  • 제31권5호
  • /
  • Pages.1361-1367
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  • 2010
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  • 0253-2964(pISSN)
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  • 1229-5949(eISSN)
대한화학회 (Korean Chemical Society)
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Synthesis and 3D-QSARs Analyses of Herbicidal O,O-Dialkyl-1-phenoxyacetoxy-1-methylphosphonate Analogues as a New Class of Potent Inhibitors of Pyruvate Dehydrogenase

  • Soung, Min-Gyu (Department of Applied Biology and Chemistry, College of Agriculture and Life Science, Chungnam National University) ;
  • Hwang, Tae-Yeon (Department of Applied Biology and Chemistry, College of Agriculture and Life Science, Chungnam National University) ;
  • Sung, Nack-Do (Department of Applied Biology and Chemistry, College of Agriculture and Life Science, Chungnam National University)
  • 투고 : 2009.10.22
  • 심사 : 2010.02.25
  • 발행 : 2010.05.20
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초록

A series of O,O-dialkyl-1-phenoxyacetoxy-1-methylphosphonate analogues (1~22) as a new class of potent inhibitors of pyruvate dehydrogenase were synthesized and 3D-QSARs (three dimensional qantitative structure-activity relationships) models on the pre-emergency herbicidal activity against the seed of cucumber (Cucumus Sativa L.) were derived and discussed quantitatively using comparative molecular field analysis (CoMFA) and comparative molecular similarity indeces analysis (CoMSIA) methods. The statistical values of CoMSIA models were better predictability and fitness than those of CoMFA models. The inhibitory activities according to the optimized CoMSIA model I were dependent on the electrostatic field (41.4%), the H-bond acceptor field (26.0%), the hydrophobic field (20.8%) and the steric field (11.7%). And also, it was found that the optimized CoMSIA model I with the sensitivity to the perturbation ($d_q{^{2'}}/dr^2{_{yy'}}$ = 0.830) and the prediction ($q^2$ = 0.503) produced by a progressive scrambling analyses were not dependent on chance correlation. From the results of graphical analyses on the contour maps with the optimized CoMSIA model I, it is expected that the structural distinctions and descriptors that subscribe to herbicidal activities will be able to apply new an herbicide design.

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피인용 문헌

  1. A perspective on the role of quantitative structure-activity and structure-property relationships in herbicide discovery vol.68, pp.4, 2012, https://doi.org/10.1002/ps.3256
  2. CoMSIA Study of a Series of N-Dichloroacetyl Oxazolidine Derivatives vol.195-196, pp.1662-7482, 2012, https://doi.org/10.4028/www.scientific.net/AMM.195-196.380
  3. Synthesis and Reactions of α-Hydroxyphosphonates vol.23, pp.6, 2018, https://doi.org/10.3390/molecules23061493