Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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A Convenient One-Pot Biginelli Reaction Catalyzed by Y(OAc)3: An Improved Protocol for the Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones and Their Sulfur Analogues

  • Aridoss, Gopalakrishnan (Division of Image Science and Information Engineering, Pukyong National University) ;
  • Jeong, Yeon-Tae (Division of Image Science and Information Engineering, Pukyong National University)
  • Published : 2010.04.20
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Abstract

Yttrium(III) acetate hydrate-catalyzed novel synthesis of 3,4-dihydropyrimidin-2(1H)-(thio)one derivatives was achieved through one-pot three-component condensation of diversified aldehydes, $\beta$-ketoesters and urea or N-methylurea or thiourea with a molar ratio of 1:1:1.4. In comparison to the classical Biginelli approach, this catalytic method has the advantages of short reaction time and improved product yield.

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References

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