Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Residue Depletion of the Sulfaquinoxaline and Trimethoprim Combination in Broilers

육계에서 설파퀴녹살린 및 트리메토프림 합제의 잔류분석

  • 임종환 (비엔씨바이오팜) ;
  • 황윤환 (충남대학교, 동물의과학연구소) ;
  • 김명석 (충남대학교, 동물의과학연구소) ;
  • 송인배 (충남대학교, 동물의과학연구소) ;
  • 박병권 (전진바이오팜) ;
  • 윤효인 (충남대학교, 동물의과학연구소)
  • Accepted : 2010.01.05
  • Published : 2010.10.30
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Abstract

Sulfaquinoxaline (SQX) and trimethoprim (TMP) are chemotherapeutics that are extensively used in various animal species for the treatment or prevention of coccidia and coccidia-like parasites. Little information about the depletion kinetics of these compounds in chickens exists in the literature. In this study, a new commercial liquid concentrate of SQX in combination with TMP (100 g/l of SQX and 33.4 g/l of TMP) was administered with drinking water at a dose of 0.75 ml/l or 1.5 ml/l. The edible tissue concentrations of the drugs were determined by the validated high-performance liquid chromatography/mass spectrometric method. Residue concentrations of SQX and TMP were lower than their maximum residual limits (MRLs) in all tissues from both dose groups at 5 days after the treatment. The optimal withdrawal time of SQX/TMP combination was suggested to be over 5 days after cessation of medication in broilers.

설파퀴녹살린과 트리메토프림 합제는 닭콕시듐병의 예방과 치료목적으로 널리 사용하고 있으나, 닭에서의 잔류에 관한 연구보고는 미흡하다. 본 연구에서는 음수첨가용 액제로 신규 개발된 설파퀴녹살린 및 트리메토프림 합제 (설파퀴녹살린, 100 g/L; 트리메토프림, 33.4 g/L)를 육계에 음수 리터당 본제 0.75 mL 및 1.5 mL를 3일간 투여한 후 살처분하여 가식부위내 잔류농도를 액체크로마토그래프/질량분석기를 이용하여 측정하였다. 그 결과 약물 투여 후 7일째에는 모든 가식부위내에서 설파퀴녹살린 및 트리메토프림은 검출되지 않았다. 따라서 신규 음수첨가용 액제인 설파퀴녹살린 및 트리메토프림 합제의 휴약기간은 최소 5일 이상으로 설정되어야 할 것이다.

Keywords

References

  1. Dagorn M, Moulin G, Laurentie M and Delmas JM. Plasma and lung pharmacokinetics of trimethoprim and sulfadiazine combinations administered to broilers. Acta Vet Scand Suppl 1991; 87: 273-275.
  2. De Baere S, Croubels S, Baert K and De Backer P. Residue depletion of sulfadiazine and trimethoprim in chickens after oral administration via drinking water. J Vet Pharmacol Ther 2000; 23: 111. https://doi.org/10.1046/j.1365-2885.2000.00250.x
  3. Korea Food and Drug Administration (KFDA). MRLs for veterinary drugs in foods. 2007: 11-1470000-001581-14.
  4. Li T, Qiao GL, Hu GZ, Meng FD, Qiu YS, Zhang XY, Guo WX, Yie HL, Li SF and Li SY. Comparative plasma and tissue pharmacokinetics and drug residue profiles of different chemotherapeutants in fowls and rabbits. J Vet Pharmacol Ther 1995; 18: 260-273. https://doi.org/10.1111/j.1365-2885.1995.tb00590.x
  5. Lindsay DS and Blagburn BL. Antiprotozoan drugs. In: Veterinary Pharmacology and Therapeutics, 7th ed., Ames, Iowa State University Press. 1995: 955-965.
  6. Loscher W, Fassbender CP, Weissing M and Kietzmann M. Drug plasma levels following administration of trimethoprim and sulphonamide combinations to broilers. J Vet Pharmacol Ther 1990; 13: 309-319. https://doi.org/10.1111/j.1365-2885.1990.tb00782.x
  7. McDougald LR. Chemotherapy of coccidiosis. In: The Biology of the Coccidia, Maryland, University Park Press. 1982: 373-427.
  8. National Veterinary Research and Quarantine Service (NVRQS). The guideline of residual analysis of veterinary drugs. 2008: NVRQS/2008/21.
  9. Piercy DW, Williams RB and White G. Evaluation of a mixture of trimethoprim and sulphaquinoxaline for the treatment of poultry: safety and palatability studies. Vet Rec 1984; 114: 60-62. https://doi.org/10.1136/vr.114.3.60
  10. Sainsbury DW. Potentiated sulphaquinoxaline used as 'strategic medication' for broiler poultry. Vet Rec 1988; 122: 395. https://doi.org/10.1136/vr.122.16.395
  11. Tu YH, Allen LV Jr, Fiorica VM and Albers DD. Pharmacokinetics of trimethoprim in the rat. J Pharm Sci 1989; 78: 556-560. https://doi.org/10.1002/jps.2600780709
  12. White G and Williams RB. Evaluation of a mixture of trimethoprim and sulphaquinoxaline for the treatment of bacterial and coccidial diseases of poultry. Vet Rec 1983; 113: 608-612.