Journal of the Korean Association of Oral and Maxillofacial Surgeons

  • 제36권5호
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  • Pages.386-391
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  • 2010
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  • 2234-7550(pISSN)
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  • 2234-5930(eISSN)
대한구강악안면외과학회 (The Korean Association of Oral and Maxillofacial Surgeons)
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치과 임플란트에서 골개조 관련인자의 발현에 관한 연구

Expression of osteoclastogenesis related factors in dental implant patients

  • 류승희 (전남대학교 치의학전문대학원 구강악안면외과학교실, 32단계 Brain Korea 21 (BK21) 치의학연구소) ;
  • 김방신 (전남대학교 치의학전문대학원 구강악안면외과학교실, 32단계 Brain Korea 21 (BK21) 치의학연구소) ;
  • 정승곤 (전남대학교 치의학전문대학원 구강악안면외과학교실, 32단계 Brain Korea 21 (BK21) 치의학연구소) ;
  • 한만승 (전남대학교 치의학전문대학원 구강악안면외과학교실, 32단계 Brain Korea 21 (BK21) 치의학연구소) ;
  • 국민석 (전남대학교 치의학전문대학원 구강악안면외과학교실, 32단계 Brain Korea 21 (BK21) 치의학연구소) ;
  • 옥승호 (전남대학교 치의학전문대학원 구강미생물학교실, 32단계 Brain Korea 21 (BK21) 치의학연구소) ;
  • 오희균 (전남대학교 치의학전문대학원 구강악안면외과학교실, 32단계 Brain Korea 21 (BK21) 치의학연구소) ;
  • 박홍주 (전남대학교 치의학전문대학원 구강악안면외과학교실, 32단계 Brain Korea 21 (BK21) 치의학연구소)
  • Ryu, Seong-Hee (Department of Oral and Maxillofacial Surgery, School of Dentistry, Dental Science Research Institute, 32nd stage of Brain Korea 21 (BK21), Chonnam National University) ;
  • Kim, Bang-Sin (Department of Oral and Maxillofacial Surgery, School of Dentistry, Dental Science Research Institute, 32nd stage of Brain Korea 21 (BK21), Chonnam National University) ;
  • Jung, Seung-Gon (Department of Oral and Maxillofacial Surgery, School of Dentistry, Dental Science Research Institute, 32nd stage of Brain Korea 21 (BK21), Chonnam National University) ;
  • Han, Man-Seung (Department of Oral and Maxillofacial Surgery, School of Dentistry, Dental Science Research Institute, 32nd stage of Brain Korea 21 (BK21), Chonnam National University) ;
  • Kook, Min-Suk (Department of Oral and Maxillofacial Surgery, School of Dentistry, Dental Science Research Institute, 32nd stage of Brain Korea 21 (BK21), Chonnam National University) ;
  • Ohk, Seung-Ho (Department of Oral Microbiology, School of Dentistry, Dental Science Research Institute, 32nd stage of Brain Korea 21 (BK21), Chonnam National University) ;
  • Oh, Hee-Kyun (Department of Oral and Maxillofacial Surgery, School of Dentistry, Dental Science Research Institute, 32nd stage of Brain Korea 21 (BK21), Chonnam National University) ;
  • Park, Hong-Ju (Department of Oral and Maxillofacial Surgery, School of Dentistry, Dental Science Research Institute, 32nd stage of Brain Korea 21 (BK21), Chonnam National University)
  • 투고 : 2010.06.04
  • 심사 : 2010.10.15
  • 발행 : 2010.10.29
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초록

Introduction: Bone resorption is a unique function of osteoclasts. Osteoclasts are a specialized macrophage polykaryon whose differentiation is regulated principally by macrophage colony-stimulating factors, receptor activator of nuclear factor ${\kappa}B$ ligand (RANK) ligand, osteoprotegerin (OPG), and interleukins (IL). Reflecting the integrin-mediated signals, osteoclasts develop a specialized cytoskeleton that allows it to establish an isolated micro-environment between itself and the bone, wherein matrix degradation occurs by a process involving proton transport. The levels of IL-1, IL-6, OPG, and prostaglandin $E_2$ ($PGE_2$) expression were evaluated to study the correlations between dental implant teeth and the adjacent teeth. Materials and Methods: The exudate of the gingival crevice acquired from dental implants, adjacent teeth, opposite teeth and contralateral teeth of 24 patients. Results: 1. The levels of IL-1, IL-6, OPG and $PGE_2$ expression in dental implant teeth were higher than those of the contralateral teeth. 2. IL-1 revealed a higher expression level in the adjacent teeth than in dental implant teeth. 3. The dental implant teeth and adjacent teeth did not show a remarkable difference in the level of IL-1 expression. 4. All the other cytokines were strongly expressed in the dental implant compared to the adjacent teeth. Conclusion: These results suggest that there might be close correlation between dental implant teeth and adjacent teeth in terms of the expressions of cytokines that affect the development and regulation of osteoclasts.

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피인용 문헌

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