Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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New Synthetic Routes to Biologically Interesting Geranylated Acetophenones from Melicope Semecarpifolia and Their Unnatural Prenylated and Farnesylated Derivatives

  • Xia, Likai (School of Chemical Engineering and Technology, Yeungnam University) ;
  • Narasimhulu, Manchala (School of Chemical Engineering and Technology, Yeungnam University) ;
  • Li, Xin (School of Chemical Engineering and Technology, Yeungnam University) ;
  • Shim, Jae-Jin (School of Chemical Engineering and Technology, Yeungnam University) ;
  • Lee, Yong-Rok (School of Chemical Engineering and Technology, Yeungnam University)
  • Published : 2010.03.20
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Abstract

This paper describes a new synthetic approach for biologically interesting geranylated acetophenones. The first total syntheses of 1-(5-geranyloxy-7-hydroxy-2,2-dimethyl-2H-chromen-8-yl)ethanone and 1-[5-geranyloxy-7-hydroxy-2-methyl-2-(4-methylpent-3-enyl)-2H-chromen-8-yl]ethanone, isolated from Melicope semecarpifolia, were carried out starting from commercially available 2,4,6-trihydroxyacetophenone.

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References

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