Reproductive and Developmental Biology

  • 제34권3호
  • /
  • Pages.117-122
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  • 2010
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  • 1738-2432(pISSN)
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  • 2288-0151(eISSN)
한국동물번식학회 (The Korean Society of Animal Reproduction)
권호 표지

수용체 접근방법에 의한 잠재적인 돼지 페로몬 성 냄새 물질의 탐색

Searching of the Potent Pig Pheromonal Odorants by Receptor Based Approach

  • 주성모 (충남대학교 농업생명과학대학 응용생물환경화학과) ;
  • 조윤기 (충남대학교 농업생명과학대학 응용생물환경화학과) ;
  • 박창식 (충남대학교 형질전환복제돼지연구센터) ;
  • 성낙도 (충남대학교 농업생명과학대학 응용생물환경화학과)
  • Joo, Sung-Mo (Department of Applied Biology & Environmental Chemistry, College of Agricultural & Life Science, Chungnam National University) ;
  • Cho, Yun-Gi (Department of Applied Biology & Environmental Chemistry, College of Agricultural & Life Science, Chungnam National University) ;
  • Park, Chang-Sik (Research Center for Transgenic Cloned Pigs, Chungnam National University) ;
  • Sung, Nack-Do (Department of Applied Biology & Environmental Chemistry, College of Agricultural & Life Science, Chungnam National University)
  • 투고 : 2005.05.17
  • 심사 : 2010.08.18
  • 발행 : 2010.09.30
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초록

To search the potent pig pheromonal odorants through receptor-based approach methods, molecular dockings between 680 Flavomets as substrate molecule and pig odorants binding proteins OBP (1HQP) and PBP (1GM6) as receptor, and QSPR (quantitative structure-property relationship) analyses from physico-chemical parameters of Flavomets and their docking scores (DS) were performed and discussed quantitatively. From the basis on the findings, the optimal value $(MSA)_{opt.}=407.595\;{\AA}^2$ of MSA (molecular surface area; ${\AA}$), and RB (number of rotational bond) had the Flavomets will be able to increase DS. Therefore, it is expected that the stearyl alcohol from DS and H-bond type between substrate and receptor would be shows the character as potent pig pheromonal odorant.

키워드

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