Annals of Hepato-Biliary-Pancreatic Surgery (한국간담췌외과학회지)

The Korean Association of Hepato-Biliary-Pancreatic Surgery (한국간담췌외과학회)
권호 표지

Histopathologic Prognostic Factors for Recurrence and Survival after Surgical Resection of Middle and Distal Bile Duct Cancer

간외 담관암의 수술적 절제 후 재발 및 생존율에 영향을 미치는 조직병리학적 예후 인자

  • Park, Ji-Young (Department of Surgery, Chonnam National University Medical School) ;
  • Kim, Ho-Hyun (Department of Surgery, Chonnam National University Medical School) ;
  • Park, Eun-Kyu (Department of Surgery, Chonnam National University Medical School) ;
  • Seoung, Jin-Shick (Department of Surgery, Chonnam National University Medical School) ;
  • Hur, Young-Hoe (Department of Surgery, Chonnam National University Medical School) ;
  • Koh, Yang-Seok (Department of Surgery, Chonnam National University Medical School) ;
  • Kim, Jung-Chul (Department of Surgery, Chonnam National University Medical School) ;
  • Cho, Chol-Kyoon (Department of Surgery, Chonnam National University Medical School) ;
  • Kim, Hyun-Jong (Department of Surgery, Chonnam National University Medical School)
  • 박지영 (전남대학교 의과대학 외과학교실) ;
  • 김호현 (전남대학교 의과대학 외과학교실) ;
  • 박은규 (전남대학교 의과대학 외과학교실) ;
  • 성진식 (전남대학교 의과대학 외과학교실) ;
  • 허영회 (전남대학교 의과대학 외과학교실) ;
  • 고양석 (전남대학교 의과대학 외과학교실) ;
  • 김정철 (전남대학교 의과대학 외과학교실) ;
  • 조철균 (전남대학교 의과대학 외과학교실) ;
  • 김현종 (전남대학교 의과대학 외과학교실)
  • Published : 2010.09.30
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Abstract

Purpose: Surgery remains the only curative option for patients with extrahepatic bile duct cancer (EHBD Ca). But, long-term survival is typically not good because of the advanced stage of disease at the time of diagnosis and frequent disease recurrence after surgical resection. The purpose of this study was to evaluate factors that influence survival and recurrence after surgical resection of EHBD Ca. Methods: A retrospective analysis of 113 patients who had received surgical resection for EHBD Ca between 2004 and 2009 was done. We investigated histopathological features, and survival and recurrence rates, and evaluated prognostic factors affecting survival and disease recurrence after surgical resection. Results: Overall survival rates for 1, 3 and 5 years were 73.2%, 42.8%, and 36.0% respectively. In univariate analysis, prognostic factors influencing survival were histologic differentiation, T stage, lymph node (LN) metastasis, TNM stage, perineural invasion (PNI), lymphovascular invasion (LVI) and resection margin state. Among them, LN metastasis, PNI and resection margin state were found to be independent prognostic factors for overall survival in multivariate analysis. Recurrence occurred in 44 patients (48.9%) and disease-free survival rates were 50.6% at 1 year and 38.3% at 3 year. Univariate analysis revealed that histologic differentiation, T stage, LN metastasis, TNM stage, PNI and LVI were significantly associated with recurrence. In multivariate analysis, only LN metastasis was found to be a significant independent predictor of recurrence. Conclusion: LN metastasis, PNI and positive resection margin were significant prognostic factors affecting survival. LN metastasis was found to be a significant independent predictor of recurrence in surgical resection of EHBD Ca.

Keywords

References

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