한국물환경학회지 (Journal of Korean Society on Water Environment)

  • 제26권6호
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  • Pages.948-953
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  • 2010
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  • 2289-0971(pISSN)
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  • 2289-098X(eISSN)
한국물환경학회 (Korean Society on Water Environment)
권호 표지

감마선 처리에 의한 에스트로겐 활성 저감 연구

Reduction of Estrogenic Activity by Gamma-ray Treatment

  • 강성욱 (고려대학교 환경생태공학부) ;
  • 서재환 (고려대학교 환경생태공학부) ;
  • 이병천 (국립환경과학원 위해성평가연구과) ;
  • 김수진 (국립환경과학원 위해성평가연구과) ;
  • 정진호 (고려대학교 환경생태공학부)
  • Kang, Sung-Wook (Division of Environmental Science & Ecological Engineering, Korea University) ;
  • Seo, Jaehwan (Division of Environmental Science & Ecological Engineering, Korea University) ;
  • Lee, Byoung Cheun (Risk Assessment Division, National Institute of Environmental Research) ;
  • Kim, Suejin (Risk Assessment Division, National Institute of Environmental Research) ;
  • Jung, Jinho (Division of Environmental Science & Ecological Engineering, Korea University)
  • 투고 : 2010.07.21
  • 심사 : 2010.09.29
  • 발행 : 2010.11.30
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초록

In this study, degradation of estrone (E1) and $17{\alpha}$-ethynylestradiol (EE2) by gamma-irradiation and subsequent reduction of estrogenic activity as a function of absorbed dose were conducted using the yeast two-hybrid assay. Relative potency of E1 and EE2 compared to estrogenic activity of $17{\beta}$-estradiol (E2) was found to be 0.0144 and 0.1605, respectively. More than 90% of E1 and EE2 (both $5.0{\times}10^{-6}M$) was removed at an absorbed dose of 5 kGy, but more than 40% of estrogenic activity still remained. The addition of $TiO_2$ catalyst appeared to improve the removal efficiency of E1 and decrease estrogenic activity while there was no significant effect for EE2. Additionally, the calculated estrogenic activity of E1 and EE2 based on a regression model was well correlated with the observed activity.

키워드

참고문헌

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