Cholesterol-lowering and Anti-obesity Effects of Polymnia Sonchifolia Poepp. & Endl. Powder in Rats Fed a High Fat-High Cholesterol Diet

야콘 분말이 고지방-고콜레스테롤 식이를 급여한 흰쥐의 콜레스테롤 저하 및 비만 억제효과에 미치는 영향

  • Published : 2010.02.27


This study was carried out to investigate the effect of Yacon (Polymnia sonchifolia Poepp. & Endl.) powder on cholesterol-lowering and anti-obesity effects in rats fed a high fat-high cholesterol diet for 4 weeks to induce hyperlipidemic and obese rat model. Weight-matched male Sprague-Dawley rats were assigned to four groups according to dietary fat, cholesterol levels and Yacon powder levels. Experimental groups were normal diet group (N), high fat-high cholesterol diet group (HFC), high fat-high cholesterol diet with 5% Yacon powder group (HFC-PSL) and high fat-high cholesterol diet with 10% Yacon powder group (HFC-PSH). The body weight gain and FER were increased by a high fat-high cholesterol diet, but gradually decreased in the Yacon powder fed groups compared with the HFC group. Food intake was lower in HFC groups compared with N group. The liver and adipose tissue weights of HFC group were heavier than those of N group, whereas those of groups administered Yacon powder were gradually decreased. The serum ALT, AST, ALP and LDH activities elevated by a high fat-high cholesterol diet were significantly decreased by Yacon powder administration. Levels of serum total cholesterol, LDL-cholesterol, atherogenic index and cardiac risk factor showed a decreasing tendency in the Yacon powder fed groups compared with HFC group. The serum HDL-cholesterol level decreased in the HFC group and markedly increased in the Yacon powder fed groups. Levels of total cholesterol and triglyceride in liver and adipose tissues were lower in Yacon powder administered groups than those in HFC group. These results suggest that Yacon powder may improve lipid metabolism of serum, liver, and adipose tissue and potentially reduce lipid storage.

본 연구는 야콘의 혈청, 간 및 지방조직의 체내 지질대사 개선효과와 항비만 효과를 살펴보기 위하여 in vivo에서 5주령 된 흰쥐 수컷 24마리를 10일간 적응시킨 후 정상식이군(N), 고지방-고콜레스테롤 식이군(HFC), 고지방-고콜레스테롤 식이와 5% 야콘 분말 첨가군(HFC-PSL) 및 고지방-고콜레스테롤 식이군과 10% 야콘 분말 첨가군(HFC-PSH)으로 나누어 4주간 실시하였다. 고지방-고콜레스테롤 식이로 증가된 체중증가량은 야콘 분말의 첨가로 농도 의존적으로 감소되었다. 고지방-고콜레스테롤 식이를 급여한 흰쥐에게 야콘 분말의 첨가는 식이섭취량에는 영향을 미치지 않았으나, 식이효율은 야콘 분말의 첨가로 유의하게 저하되었다. 고지방-고콜레스테롤 식이로 증가되어진 부고환 및 장간막 지방조직의 무게는 야콘 분말의 급여로 유의하게 저하되었으나, 간조직 무게에는 영향을 미치지 않았다. 혈청 중 ALT, AST, ALP 및 LDH 활성도 야콘 분말의 첨가로 고지방-고콜레스테롤 식이군(HFC)에 비하여 저하되었다. 혈청 중 중성지방 함량의 경우, 고지방-고콜레스테롤 식이군들(HFC, HFC-PSL, HFC-PSH) 간의 유의차가 없었으나, 혈청 중 총콜레스테롤 함량은 야콘 분말 첨가에 따라 농도 의존적으로 감소하였다. 야콘 분말의 급여로 인하여 고지방-고콜레스테롤 식이로 감소된 혈청 HDL-콜레스테롤 함량은 증가되었고, 고지방-고콜레스테롤 식이로 증가된 혈청 LDL-콜레스테롤 함량과 동맥경화지수 및 심혈관위험지수는 유의하게 감소되었다. 고지방-고콜레스테롤 식이로 증가된 간조직 및 지방조직의 중성지방 및 총콜레스테롤 함량은 야콘분말의 급여로 감소하였으며, 특히 부고환지방조직의 총콜레스테롤 함량과 장간막지방조직의 중성 지방 함량은 정상식이군(N)과도 비슷한 경향이었다. 이상의 실험 결과 흰쥐에게 고지방-고콜레스테롤 식이와 함께 급여한 야콘 분말은 체중, 간 및 지방조직의 무게 감소와 더불어 혈청 및 지방조직의 지질대사 개선에 긍정적인 영향을 미치는 것으로 나타났다. 이러한 결과는 야콘 분말에 함유된 식이섬유소인 inulin과 fructo-oligo당 등 생리활성 물질에 의해 지방조직의 체지방 형성을 억제함으로써 항비만 효과 및 체내 지질대사 개선과 심혈관계 질환 예방 효과를 나타낼 수 있을 것으로 생각되어지나, 이외의 성분이 어떻게 고지혈증 및 비만을 억제시킬 수 있는지는 추후 더 연구되어야 할 것으로 사료된다.



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