Journal of Pharmaceutical Investigation

한국약제학회 (The Korean Society of Pharmaceutical Sciences and Technology)
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Controlled-Release Pelletized Dosage Forms Using the Extrusion-Spheronization Process

  • Rhee, Yun-Seok (School of Pharmacy, Sungkyunkwan University) ;
  • Lee, Jae-Hwi (College of Pharmacy, Chung-Ang University) ;
  • Lee, Beom-Jin (Bioavailability Control Laboratory, College of Pharmacy, Kangwon National University) ;
  • Park, Eun-Seok (School of Pharmacy, Sungkyunkwan University)
  • 투고 : 2010.08.17
  • 심사 : 2010.10.07
  • 발행 : 2010.12.20
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초록

Pellets, which are multiple-unit dosage systems, have the several therapeutic advantages over single-unit dosage systems in oral drug delivery. This review focuses on the current status and explores extrusion-spheronization technique with special attention to controlled-release application of pellets including coated pellets for delayed release formulations, coated pellets for colon delivery, coated pellets for sustained drug delivery, sustained-release matrix pellets, pellets compressed into tablets, bioadhesive pellets, floating pellets, and pelletization with solubilization techniques.

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참고문헌

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