Journal of Pharmaceutical Investigation

  • 제40권6호
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  • Pages.373-378
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  • 2010
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  • 2093-5552(pISSN)
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  • 2093-6214(eISSN)
한국약제학회 (The Korean Society of Pharmaceutical Sciences and Technology)
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Enhanced Occlusiveness of Nanostructured Lipid Carrier (NLC)-based Carbogel as a Skin Moisturizing Vehicle

  • Choi, Woo-Sik (Division of Pharmaceutical Science, College of Pharmacy, Chung-Ang University) ;
  • Cho, Hye-In (Division of Pharmaceutical Science, College of Pharmacy, Chung-Ang University) ;
  • Lee, Hyun-Young (Division of Pharmaceutical Science, College of Pharmacy, Chung-Ang University) ;
  • Lee, Seo-Hyun (Division of Pharmaceutical Science, College of Pharmacy, Chung-Ang University) ;
  • Choi, Young-Wook (Division of Pharmaceutical Science, College of Pharmacy, Chung-Ang University)
  • 투고 : 2010.11.12
  • 심사 : 2010.11.27
  • 발행 : 2010.12.20
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초록

In order to develop a topical preparation which has a high occlusive property with skin moisturization, nano-structured lipid carrier (NLC) systems along with solid lipid nanoparticle (SLN) were designed. Various NLC dispersions were successfully formulated with Compritol 888 ATO as a solid lipid, Labrafil M 1944 CS as an oil, and Tween 80 as a surfactant. The increase of oil content (5 to 50%) led to the decrease in the occlusion factor in the order of SLN > NLC-5 > NLC-15 = NLC-30 > NLC-50. Particle size of lipid particulates was in the range of 100 to 160 nm. NLC-based carbogels were prepared by the employment of humectants such as urea, glycerin, and Tinocare GL to carbomer gel. NLC-30 gel formulations containing 4 or 8 % of lipid particles showed improved occlusive effect in vitro, compared to NLC-free gel base. Even though NLC-free gel base revealed comparable occlusion effect by itself, the occlusion factor of 4 % NLC-30 gel was about 2-fold higher than that of NLC-free gel base.

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참고문헌

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피인용 문헌

  1. Topical formulation of retinyl retinoate employing nanostructured lipid carriers vol.42, pp.5, 2012, https://doi.org/10.1007/s40005-012-0036-1
  2. skin permeation of solid lipid nanoparticles for transdermal delivery of quercetin vol.36, pp.6, 2014, https://doi.org/10.1111/ics.12160