KSBB Journal

The Korean Society for Biotechnology and Bioengineering (한국생물공학회)
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Preparation of PEG Microparticles Containing Coriander Essential Oil Using Supercritical PGSS Process

초임계 PGSS 공정을 이용한 Coriander 정유 함유 PEG 미세입자 제조

  • Choi, Jin-Ah (Department of Chemical Engineering, The University of Suwon) ;
  • Lim, Gio-Bin (Department of Chemical Engineering, The University of Suwon) ;
  • Ryu, Jong-Hoon (Department of Chemical Engineering, The University of Suwon)
  • Received : 2010.07.14
  • Accepted : 2010.08.24
  • Published : 2010.08.31
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Abstract

In the present study, biocompatible poly (ethylene glycol) (PEG) microparticles containing coriander essential oil were prepared using a supercritical particles from gas saturated solution (PGSS) process to improve the stability of the coriander oil. The effects of various process parameters such as temperature, pressure, and nozzle diameter on the morphology and entrapment efficiency of coriander oil loaded PEG microparticles were then investigated. A positive influence on the formation of spherical microparticles was observed with increasing temperature and decreasing pressure. Furthermore, somewhat more porous microparticles were produced with an increase in pressure. At a given temperature, the highest entrapment efficiency of coriander essential oil in PEG microparticles was observed under the lowest experimental pressure condition.

본 연구에서는 coriander 정유의 안정성 향상을 위해 초임계 PGSS 공정을 이용하여 coriander 정유가 봉입된 PEG 미세입자를 제조하였으며 공정 온도와 압력, 노즐 크기가 미세입자의 크기, 형태 및 정유의 봉입률에 미치는 영향에 대하여 조사하였다. $100\;{\mu}m$ 노즐을 사용하여 얻어진 미세입자의 형상을 분석한 결과 $1-10\;{\mu}m$ 크기의 구형 입자 형태를 나타내었으나 노즐의 크기가 증가한 경우에는 덩어리진 입자가 얻어짐을 확인하였다. 온도, 압력 변화에 따라 얻어진 미세입자의 경우 일정 압력 조건에서 공정 온도가 높아짐에 따라, 일정 온도 조건에서 공정 압력이 낮아짐에 따라 구형입자 비율이 증가함을 보였으며, 일정 온도 조건에서는 공정 압력이 높아짐에 따라 더 많은 기공을 가지는 입자가 생성됨을 확인하였다. 제조된 PEG 미세입자 내 coriander 정유의 봉입률은 모든 온도 조건에서 가장 낮은 압력인 75 bar일 때 가장 높은 값을 보였다.

Keywords

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