KSBB Journal

The Korean Society for Biotechnology and Bioengineering (한국생물공학회)
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Preparation and Evaluation of Adhesive Hydrogel of Ketoprofen Using Microsphere System

마이크로스피어 시스템을 이용한 케토프로펜 점착성 하이드로겔의 제조 및 평가

  • Cho, Young-Ho (Department of Pharmaceutical Engineering, Konyang University) ;
  • Lee, Gye-Won (Department of Pharmaceutical Engineering, Konyang University)
  • Received : 2010.01.25
  • Accepted : 2010.06.16
  • Published : 2010.06.30
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Abstract

Ketoprofen is one of the propionic acid class of nonsteroidal anti-inflammatory drug with analgesic and antipyretic effects. The most common side effects from ketoprofen after oral administration are gastrointestinal irritation, diarrhea, abdominal pain and retention of fluid. Ketoprofen was formulated as water-soluble gels to reduce these side effects. To increase the skin permeability of ketoprofen, microsphere containing ketoprofen was prepared with chitosan and ploy-$\varepsilon$-caprolactone. And then prepared microsphere was manufactured as an adhesive hydrogel with polyvinylpyrrolidone K-25, polyethylene glycol 4000, and various permeation enhancers. The flux and permeability of ketoprofen were evaluated. As the concentration of tween 80 and enhancers increased, the flux of ketroprofen was accelerated. Also the permeation rate was facilitated by enhancers, but did not affect the lag time. From these results, the adhesive hydrogel using microsphere could be a good delivery system for ketoprofen to improve the skin permeation.

Keywords

References

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