한국자원식물학회지 (Korean Journal of Plant Resources)

  • 제23권6호
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  • Pages.513-518
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  • 2010
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  • 1226-3591(pISSN)
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  • 2287-8203(eISSN)
한국자원식물학회 (The Plant Resources Society of Korea)
권호 표지

The Analgesic Effect and Mechanisms of Dianthus chinensis L Extract in the mice.

  • Park, Soo-Hyun (Department of Pharmacology, College of Medicine, Hallym University) ;
  • Sim, Yun-Beom (Department of Pharmacology, College of Medicine, Hallym University) ;
  • Lee, Jin-Koo (Department of Pharmacology, College of Medicine, Hallym University) ;
  • Lim, Soon-Sung (Institute of Natural Medicine, College of Medicine, Hallym University) ;
  • Kim, Jin-Kyu (Institute of Natural Medicine, College of Medicine, Hallym University) ;
  • Suh, Hong-Won (Department of Pharmacology, College of Medicine, Hallym University)
  • 투고 : 2010.05.24
  • 심사 : 2010.10.14
  • 발행 : 2010.12.31
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초록

In the present study, the antinociceptive profiles of Dianthus chinensis L extract were examined in ICR mice. Dianthus chinensis L extract administered orally (200 mg/kg) showed an antinociceptive effect as measured by the tail-flick and hot-plate tests. In addition, Dianthus chinensis L extract attenuated the writhing numbers in the acetic acid-induced writhing test. Furthermore, the cumulative nociceptive response time for intrathecal (i.t.) injection of substance P ($0.7\;{\mu}g$) was diminished by Dianthus chinensis L extract. Intraperitoneal (i.p.) pretreatment with yohimbine ($\alpha_2$-adrenergic receptor antagonist) attenuated antinociceptive effect induced by Dianthus chinensis L extract in the writhing test. However, naloxone (opioid receptor antagonist) or methysergide (5-HT serotonergic receptor antagonist) did not affect antinociception induced by Dianthus chinensis L extract in the writhing test. Our results suggest that Dianthus chinensis L extract shows an antinociceptive property in various pain models. Furthermore, this antinociceptive effect of Dianthus chinensis L extract may be mediated by $\alpha_2$-adrenergic receptor, but not opioidergic and serotonergic receptors.

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